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The Use of N, N-Diethyl-m-Toluamide to Enhance Dermal and Transdermal Delivery of Drugs

A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Di-ethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1982-11, Vol.71 (11), p.1211-1213
Main Authors: Windheuser, John J., Haslamx, John L., Caldwell, Larry, Shaffer, Richard D.
Format: Article
Language:English
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Summary:A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Di-ethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusion cell model. A topically applied steroid, hydrocortisone, has been used to demonstrate the in vivo effectiveness of I on human skin. The degree of pallor produced on human skin by the corticosteroids was used as a measure of the relative delivery of hydrocortisone from formulations with and without I.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600711107