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The Use of N, N-Diethyl-m-Toluamide to Enhance Dermal and Transdermal Delivery of Drugs
A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Di-ethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in...
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Published in: | Journal of pharmaceutical sciences 1982-11, Vol.71 (11), p.1211-1213 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Di-ethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusion cell model. A topically applied steroid, hydrocortisone, has been used to demonstrate the in vivo effectiveness of I on human skin. The degree of pallor produced on human skin by the corticosteroids was used as a measure of the relative delivery of hydrocortisone from formulations with and without I. |
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ISSN: | 0022-3549 1520-6017 |
DOI: | 10.1002/jps.2600711107 |