The Use of N, N-Diethyl-m-Toluamide to Enhance Dermal and Transdermal Delivery of Drugs

• Published in: Journal of pharmaceutical sciences 1982-11, Vol.71 (11), p.1211-1213
• Main Authors: Windheuser, John J., Haslamx, John L., Caldwell, Larry, Shaffer, Richard D.
• Format: Article
• Language: English
• Subjects: Animals; Benzamides - pharmacology; Chromatography, High Pressure Liquid - methods; DEET - pharmacology; Delivery; Delivery, drug—dermal and transdermal, N,N‐diethyl‐m‐toluamide enhancement, hydrocortisone; dermal and transdermal delivery; Diffusion; drug-dermal and transdermal; Excipients; Humans; hydrocortisone; Hydrocortisone - metabolism; Hydrocortisone-enhancement of N; Hydrocortisone— enhancement of N,N-diethyl-m-toluamide on drug delivery, dermal and transdermal delivery; Keyphrases; Mice; Mice, Hairless; N,N-Diethyl-m-toluamide—enhancement of dermal and transdermal drug delivery, hydrocortisone; N-diethyl-m-toluamide enhancement; N-diethyl-m-toluamide on drug delivery; N-Diethyl-m-toluamide-enhancement of dermal and transdermal drug delivery; Ointments; Skin Absorption - drug effects; Time Factors
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600711107

A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Di-ethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusion cell model. A topically applied steroid, hydrocortisone, has been used to demonstrate the in vivo effectiveness of I on human skin. The degree of pallor produced on human skin by the corticosteroids was used as a measure of the relative delivery of hydrocortisone from formulations with and without I.