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Effects of human alveolar macrophages and periphera blood monocytes on Toxoplasma gondii Legend

The initial uptake of T. gondii by alveolar macrophages and peripheral blood monocytes from individuals who smoke was the same in 10 experiments; however, the difference between the percentage of infected monocytes and alveolar macrophages 20 hr after challenge was significant, demonstrating that hu...

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Bibliographic Details
Published in:The Journal of infectious diseases 1983-01, Vol.147 (4), p.957-957
Main Authors: McLeod, R, Estes, R, Mack, D G, McLeod, E G
Format: Article
Language:English
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Summary:The initial uptake of T. gondii by alveolar macrophages and peripheral blood monocytes from individuals who smoke was the same in 10 experiments; however, the difference between the percentage of infected monocytes and alveolar macrophages 20 hr after challenge was significant, demonstrating that human alveolar macrophages eliminate intracellular T. gondii but do so less effectively than monocytes. Chronic, latent infection with T. gondii did not improve the microbicidal ability of alveolar macrophages; microbicidal capacity was greater when alveolar macrophages were cultured in medium 199 and 40% autologous serum than in Neumann and Tytell medium.
ISSN:0022-1899