Uptake, tissue distribution, and metabolism of malachite green in the channel catfish (Ictalurus punctatus)

Channel catfish (Ictalurus punctatus) were injected intravascularly with 0.8 mg malachite green per kg. Blood specimens were collected at intervals up to 10 hours. Other fish were exposed to water containing 0.8 mg carbon-14 labelled malachite green per litre for 1 hour. Distribution of malachite gr...

Full description

Saved in:
Bibliographic Details
Published in:Canadian journal of fisheries and aquatic sciences 1996-06, Vol.53 (6), p.1427-1433
Main Authors: Plakas, S M, El Said, K R, Stehly, G R, Gingerich, W H, Allen, J L
Format: Article
Language:English
Subjects:
Animal aquaculture
Animal productions
Biological and medical sciences
Freshwater
Fundamental and applied biological sciences. Psychology
Ictalurus punctatus
Pisciculture
Vertebrate aquaculture
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Channel catfish (Ictalurus punctatus) were injected intravascularly with 0.8 mg malachite green per kg. Blood specimens were collected at intervals up to 10 hours. Other fish were exposed to water containing 0.8 mg carbon-14 labelled malachite green per litre for 1 hour. Distribution of malachite green in the tissues of the fish was determined at intervals up to 336 hours. After intravascular dosing, mean plasma concentrations of malachite green showed a triphasic decline with an elimination terminal half-life of 6.2 hours. The dye was rapidly absorbed during waterborne exposure. Elimination after exposure was triphasic with a terminal half-life of 4.7 hours. In muscle, the half-life was approximately 67 hours. Malachite green and its metabolites were widely distributed in all tissues. Total drug equivalent concentrations in fish exposed to radiocarbon labelled dye were highest in abdominal fat and lowest in plasma. The dye was rapidly and extensively metabolized to leucomalachite green which was slowly eliminated from tissues. Leucomalachite green was an appropriate target analyte for monitoring exposure of channel catfish to malachite green.
ISSN:0706-652X
1205-7533
DOI:10.1139/f96-061