Reevaluation of glypican-3 as a serological marker for hepatocellular carcinoma

Glypican-3 (GPC3) is a novel histochemical marker of hepatocellular carcinoma (HCC). However, its utility as a serologic marker for HCC is not conclusive. A total of 1037 subjects, including 155 patients with HCC, 180 with chronic hepatitis, 124 with liver cirrhosis, 442 with non-HCC cancer and 136...

Full description

Saved in:
Bibliographic Details
Published in:Clinica chimica acta 2013-08, Vol.423, p.105-111
Main Authors: Chen, Min, Li, Guohua, Yan, Jian, Lu, Xiuzhi, Cui, Jianwei, Ni, Zhengxian, Cheng, Weizhong, Qian, Gengsun, Zhang, Jing, Tu, Hong
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor - blood
Carcinoma, Hepatocellular - blood
Cell Line, Tumor
Enzyme-Linked Immunosorbent Assay - standards
Female
Gene Expression Regulation, Neoplastic
Glypican-3
Glypicans - blood
Hep G2 Cells
Hepatocellular carcinoma
Humans
Immunohistochemistry
Liver Neoplasms - blood
Male
Middle Aged
Neoplasms - blood
Reference Standards
Sensitivity and Specificity
Serological marker
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glypican-3 (GPC3) is a novel histochemical marker of hepatocellular carcinoma (HCC). However, its utility as a serologic marker for HCC is not conclusive. A total of 1037 subjects, including 155 patients with HCC, 180 with chronic hepatitis, 124 with liver cirrhosis, 442 with non-HCC cancer and 136 healthy controls, were analyzed for serum GPC3 (sGPC3) by an ELISA constructed with 2 monoclonal antibodies. The average level of sGPC3 in HCC patients was 99.94±267.2ng/ml, which was significantly higher than in patients with chronic hepatitis (10.45±46.02ng/ml, P
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2013.04.026