Comorbidity and outcomes after surgery among women with breast cancer: analysis of nationwide in-patient sample database

To examine the effect of comorbidity on risk of postoperative complications, prolonged hospitalization (defined as above median length of stay), non-routine disposition, and in-patient death among women with breast cancer after surgery. Nationwide in-patient sample is a nationwide clinical and admin...

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Bibliographic Details
Published in:Breast cancer research and treatment 2013-06, Vol.139 (2), p.469-476
Main Authors: Dehal, Ahmed, Abbas, Ali, Johna, Samir
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Biological and medical sciences
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - surgery
Cancer research
Cancer surgery
Cancer therapies
Comorbidity
Epidemiology
Female
Gynecology. Andrology. Obstetrics
Health aspects
Humans
Mammary gland diseases
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Oncology
Patient Outcome Assessment
Patient outcomes
Retrospective Studies
Risk Factors
Surgical outcomes
Tumors
Women
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Summary:To examine the effect of comorbidity on risk of postoperative complications, prolonged hospitalization (defined as above median length of stay), non-routine disposition, and in-patient death among women with breast cancer after surgery. Nationwide in-patient sample is a nationwide clinical and administrative database. Discharges of patients aged 40 years and older who underwent surgery for breast cancer from 2005 to 2009 were identified. Information about patients and hospitals characteristics were obtained. Comorbidities were identified and used to calculate Charlson comorbidity index (CCI) score. We divided patients based on these scores into four groups: 0, 1, 2, and ≥3. Multivariate logistic regression analyses were used to examine risk adjusted association between CCI score and the aforementioned outcomes. We identified 70,536 patients’ discharges. Compared to a CCI score of zero as a reference group, CCI scores of 1, 2, and ≥3 increased the risk of post-operative complications by 1.7-fold, 2.6-fold, and 4.6-fold, respectively ( p  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-013-2543-9