Inhibition of human B-cell development into plasmablasts by histone deacetylase inhibitor valproic acid

In particular, VPA ameliorates the pathogenesis of experimental autoimmune encephalomyelitis,E1 decreases the incidence and severity of collagen-induced arthritis,E2 and attenuates inflammation in autoimmune neuritis.E3In vitro treatment of human dendritic cells with VPA impairs their migratory capa...

Full description

Saved in:
Bibliographic Details
Published in:Journal of allergy and clinical immunology 2013-06, Vol.131 (6), p.1695-1699.e9
Main Authors: Kienzler, Anne-Kathrin, MSc, Rizzi, Marta, MD, PhD, Reith, Maike, MSc, Nutt, Stephen L., PhD, Eibel, Hermann, PhD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens
B-Lymphocytes - drug effects
B-Lymphocytes - metabolism
Cell Dedifferentiation - drug effects
Cell Proliferation - drug effects
Cell Survival - drug effects
Histone Deacetylase Inhibitors - pharmacology
Humans
Immune system
Immunoglobulins
Immunophenotyping
Kinases
Phenotype
Rodents
Valproic Acid - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In particular, VPA ameliorates the pathogenesis of experimental autoimmune encephalomyelitis,E1 decreases the incidence and severity of collagen-induced arthritis,E2 and attenuates inflammation in autoimmune neuritis.E3In vitro treatment of human dendritic cells with VPA impairs their migratory capability and potential to effectively activate T cells.3 Furthermore, HDAC inhibition suppresses T-cell proliferation,E4 increases TH2 cytokine production,E5 and induces suppressive function of regulatory T cells.E6 Humoral immune responses against bacteria are maintained by immunoglobulin-secreting plasma cells and memory B cells. [...]membranes were incubated in SuperSignal West Femto Maximum Sensitivity Substrate or in SuperSignal West Pico Chemiluminescent Substrate (Thermo Scientific, Waltham, Mass).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2013.01.018