Evaluation of lasersurgery and radiotherapy as treatment modalities in early stage laryngeal carcinoma: tumour outcome and quality of voice

For treatment of early stage (Tis-T2) laryngeal cancer the main choice is between microlaryngoscopy with carbon dioxide laser resection (laser surgery) and radiotherapy. Because both treatments provide excellent tumour control, secondary outcome variables such, as quality of voice may be of importan...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2013-07, Vol.270 (7), p.2079-2087
Main Authors: Remmelts, A. J., Hoebers, F. J. P., Klop, W. M. C., Balm, A. J. M., Hamming-Vrieze, O., van den Brekel, M. W. M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - radiotherapy
Carcinoma, Squamous Cell - surgery
Female
Follow-Up Studies
Head and Neck Surgery
Humans
Laryngeal Neoplasms - radiotherapy
Laryngeal Neoplasms - surgery
Laryngology
Lasers, Gas - therapeutic use
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Neurosurgery
Otorhinolaryngology
Postoperative Complications
Surveys and Questionnaires
Treatment Outcome
Voice Disorders - etiology
Voice Quality
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Summary:For treatment of early stage (Tis-T2) laryngeal cancer the main choice is between microlaryngoscopy with carbon dioxide laser resection (laser surgery) and radiotherapy. Because both treatments provide excellent tumour control, secondary outcome variables such, as quality of voice may be of importance in treatment preference. In this study tumour outcomes and quality of voice were analysed for a cohort of patients with early stage (Tis-T2) laryngeal (glottic) carcinoma. The “physical subscale” of the voice handicap index questionnaire (VHI) and a validated five-item screening questionnaire were used. Analysis of 89 patients treated with laser surgery and 159 patients treated with radiotherapy revealed a 5-year local control of 75 and 86 % ( p  = 0.07). Larynx preservation (5-year) was, however, superior in patients treated with laser surgery, 93 vs 83 % ( p  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-013-2460-x