Gastro-oesophageal reflux disease

Summary Gastro-oesophageal reflux disease is one of the most common disorders of the gastrointestinal tract. Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymo...

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Bibliographic Details
Published in:The Lancet (British edition) 2013-06, Vol.381 (9881), p.1933-1942
Main Authors: Bredenoord, Albert J, MD, Pandolfino, John E, MD, Smout, André JPM, Prof
Format: Article
Language:English
Subjects:
Abdomen
Acids
Alginates - therapeutic use
Antacids - therapeutic use
Biological and medical sciences
Chronic Disease
Diet
Digestive system
Ear diseases
Esophagoscopy - methods
Esophagus
Fundoplication - methods
Gastric Acid - physiology
Gastric Emptying - physiology
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - diagnosis
Gastroesophageal Reflux - etiology
Gastroesophageal Reflux - therapy
Gastrointestinal tract
General aspects
Helicobacter Infections - complications
Helicobacter pylori
Humans
Hydrogen-Ion Concentration
Internal Medicine
Life Style
Manometry - methods
Medical sciences
Other diseases. Semiology
Pressure
Radiology
Sleep
Treatment Outcome
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Description
Summary:Summary Gastro-oesophageal reflux disease is one of the most common disorders of the gastrointestinal tract. Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymous with hiatus hernia. After the advent of the flexible endoscope, reflux disease was, for a period, equated to oesophagitis. The introduction of oesophageal pH monitoring made us believe that reflux disease could be defined by an abnormally high proportion of time with oesophageal pH less than 4. Moreover, the successive arrival of histamine-2-receptor antagonists and proton-pump inhibitors changed our idea of treatment for the disease, with swings from and towards surgery, endoscopic techniques, and alternative pharmaceutical options.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(12)62171-0