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Gastro-oesophageal reflux disease
Summary Gastro-oesophageal reflux disease is one of the most common disorders of the gastrointestinal tract. Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymo...
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Published in: | The Lancet (British edition) 2013-06, Vol.381 (9881), p.1933-1942 |
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container_end_page | 1942 |
container_issue | 9881 |
container_start_page | 1933 |
container_title | The Lancet (British edition) |
container_volume | 381 |
creator | Bredenoord, Albert J, MD Pandolfino, John E, MD Smout, André JPM, Prof |
description | Summary Gastro-oesophageal reflux disease is one of the most common disorders of the gastrointestinal tract. Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymous with hiatus hernia. After the advent of the flexible endoscope, reflux disease was, for a period, equated to oesophagitis. The introduction of oesophageal pH monitoring made us believe that reflux disease could be defined by an abnormally high proportion of time with oesophageal pH less than 4. Moreover, the successive arrival of histamine-2-receptor antagonists and proton-pump inhibitors changed our idea of treatment for the disease, with swings from and towards surgery, endoscopic techniques, and alternative pharmaceutical options. |
doi_str_mv | 10.1016/S0140-6736(12)62171-0 |
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Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymous with hiatus hernia. After the advent of the flexible endoscope, reflux disease was, for a period, equated to oesophagitis. The introduction of oesophageal pH monitoring made us believe that reflux disease could be defined by an abnormally high proportion of time with oesophageal pH less than 4. Moreover, the successive arrival of histamine-2-receptor antagonists and proton-pump inhibitors changed our idea of treatment for the disease, with swings from and towards surgery, endoscopic techniques, and alternative pharmaceutical options.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(12)62171-0</identifier><identifier>PMID: 23477993</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Abdomen ; Acids ; Alginates - therapeutic use ; Antacids - therapeutic use ; Biological and medical sciences ; Chronic Disease ; Diet ; Digestive system ; Ear diseases ; Esophagoscopy - methods ; Esophagus ; Fundoplication - methods ; Gastric Acid - physiology ; Gastric Emptying - physiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - diagnosis ; Gastroesophageal Reflux - etiology ; Gastroesophageal Reflux - therapy ; Gastrointestinal tract ; General aspects ; Helicobacter Infections - complications ; Helicobacter pylori ; Humans ; Hydrogen-Ion Concentration ; Internal Medicine ; Life Style ; Manometry - methods ; Medical sciences ; Other diseases. Semiology ; Pressure ; Radiology ; Sleep ; Treatment Outcome</subject><ispartof>The Lancet (British edition), 2013-06, Vol.381 (9881), p.1933-1942</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. 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Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymous with hiatus hernia. After the advent of the flexible endoscope, reflux disease was, for a period, equated to oesophagitis. The introduction of oesophageal pH monitoring made us believe that reflux disease could be defined by an abnormally high proportion of time with oesophageal pH less than 4. Moreover, the successive arrival of histamine-2-receptor antagonists and proton-pump inhibitors changed our idea of treatment for the disease, with swings from and towards surgery, endoscopic techniques, and alternative pharmaceutical options.</description><subject>Abdomen</subject><subject>Acids</subject><subject>Alginates - therapeutic use</subject><subject>Antacids - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Diet</subject><subject>Digestive system</subject><subject>Ear diseases</subject><subject>Esophagoscopy - methods</subject><subject>Esophagus</subject><subject>Fundoplication - methods</subject><subject>Gastric Acid - physiology</subject><subject>Gastric Emptying - physiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - diagnosis</subject><subject>Gastroesophageal Reflux - etiology</subject><subject>Gastroesophageal Reflux - therapy</subject><subject>Gastrointestinal tract</subject><subject>General aspects</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Internal Medicine</subject><subject>Life Style</subject><subject>Manometry - methods</subject><subject>Medical sciences</subject><subject>Other diseases. 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Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - diagnosis</topic><topic>Gastroesophageal Reflux - etiology</topic><topic>Gastroesophageal Reflux - therapy</topic><topic>Gastrointestinal tract</topic><topic>General aspects</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Internal Medicine</topic><topic>Life Style</topic><topic>Manometry - methods</topic><topic>Medical sciences</topic><topic>Other diseases. 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Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymous with hiatus hernia. After the advent of the flexible endoscope, reflux disease was, for a period, equated to oesophagitis. The introduction of oesophageal pH monitoring made us believe that reflux disease could be defined by an abnormally high proportion of time with oesophageal pH less than 4. Moreover, the successive arrival of histamine-2-receptor antagonists and proton-pump inhibitors changed our idea of treatment for the disease, with swings from and towards surgery, endoscopic techniques, and alternative pharmaceutical options.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23477993</pmid><doi>10.1016/S0140-6736(12)62171-0</doi><tpages>10</tpages></addata></record> |
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subjects | Abdomen Acids Alginates - therapeutic use Antacids - therapeutic use Biological and medical sciences Chronic Disease Diet Digestive system Ear diseases Esophagoscopy - methods Esophagus Fundoplication - methods Gastric Acid - physiology Gastric Emptying - physiology Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - diagnosis Gastroesophageal Reflux - etiology Gastroesophageal Reflux - therapy Gastrointestinal tract General aspects Helicobacter Infections - complications Helicobacter pylori Humans Hydrogen-Ion Concentration Internal Medicine Life Style Manometry - methods Medical sciences Other diseases. Semiology Pressure Radiology Sleep Treatment Outcome |
title | Gastro-oesophageal reflux disease |
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