Complications and Quality of Life After Template-assisted Transperineal Prostate Biopsy in Patients Eligible for Focal Therapy

• Published in: Urology (Ridgewood, N.J.) N.J.), 2013-06, Vol.81 (6), p.1291-1296
• Main Authors: Losa, Andrea, Gadda, Giulio Maria, Lazzeri, Massimo, Lughezzani, Giovanni, Cardone, Giampiero, Freschi, Massimo, Lista, Giuliana, Larcher, Alessandro, Nava, Luciano Dante, Guazzoni, Giorgio
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Biopsy, Needle - adverse effects; Chi-Square Distribution; Hematoma - etiology; Hematuria - etiology; Hemospermia - etiology; Humans; Male; Medical sciences; Middle Aged; Neoplasm Grading; Nephrology. Urinary tract diseases; Perineum; Prostate - pathology; Prostatic Neoplasms - pathology; Prostatic Neoplasms - therapy; Quality of Life; Statistics, Nonparametric; Surveys and Questionnaires; Urinary Retention - etiology; Urology
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2012.11.078

Objective To assess the complication rates and quality of life in patients eligible for focal therapy who underwent template-assisted transperineal prostate biopsy (TTPB). Materials and Methods Eighty-seven patients with low-risk prostate cancer (clinical stage T1c-T2a, prostate-specific antigen level ≤10 ng/mL, biopsy Gleason score ≤6), who were candidates for focal therapy, underwent TTPB. The study details are available from http://clinicaltrials.gov ( NCT00928603 ). The primary outcomes were the complication rates, according to the Clavien-Dindo classification, and changes in the quality of life, evaluated using the International Prostate Symptom Score, International Index of Erectile Function, and Functional Assessment of Cancer Therapy-Prostate questionnaires, before and 1 month after TTPB. Results The median patient age was 63.9 years (range 46-78), with a median Charlson comorbidity index of 2.2 (range 0-4). No statistically significant differences were observed when comparing the general and/or specific domains of the International Prostate Symptom Score, International Index of Erectile Function, and Functional Assessment of Cancer Therapy-Prostate results before and 1 month after TTPB ( P >.05 for all). Using the Clavien-Dindo classification, we observed 37 cases of grade 1 complications, including 5 (6.1%) cases of macrohematuria, 13 (16%) of hemospermia, 11 (13.5%) of perineal hematoma, 3 (3.7%) of perineal hematoma and hemospermia, and 5 (6.1%) of macrohematuria and hemospermia. Three patients (3.7%) developed a grade II complication (ie, acute urinary retention). Prostate cancer was detected in 54 patients (62.1%). Of 57 patients, 16 (29.6%) were upgraded from Gleason score 3+3/atypical small acinar proliferation to Gleason score 7. Of the 54 patients with positive TTPB findings, 18 (25.3%) showed an anatomic correspondence between the results of previous biopsies and TTPB. Conclusion TTPB did not appear to have a significant effect on the quality of life of candidates for focal therapy, and the Clavien-Dindo complication rate was negligible.