Epithelial Cell Adhesion Molecule-positive Circulating Tumor Cells as Predictive Biomarker in Patients With Prostate Cancer

• Published in: Urology (Ridgewood, N.J.) N.J.), 2013-06, Vol.81 (6), p.1303-1307
• Main Authors: Amato, Robert J, Melnikova, Vladislava, Zhang, Yujian, Liu, Wen, Saxena, Somyata, Shah, Parth K, Jensen, Brett T, Torres, Karen E, Davis, Darren W
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Antigens, Neoplasm - metabolism; Biological and medical sciences; Biomarkers, Tumor - blood; Bone Neoplasms - blood; Bone Neoplasms - secondary; Cell Adhesion Molecules - metabolism; Epithelial Cell Adhesion Molecule; Gynecology. Andrology. Obstetrics; Humans; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Male genital diseases; Medical sciences; Middle Aged; Neoplasm Grading; Neoplastic Cells, Circulating - metabolism; Nephrology. Urinary tract diseases; Proportional Hazards Models; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - pathology; Retrospective Studies; Testosterone - blood; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urology
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2012.10.041

Objective To assess the use of circulating tumor cells (CTCs) as a longitudinal endpoint factor for clinical monitoring of patients with prostate cancer and to evaluate the association among the baseline CTC number, various clinical characteristics, and survival. Materials and Methods The CTCs were enumerated using the CellSearch Food and Drug Administration–cleared CTC kit in 202 patients with prostate cancer. Variables, including metastatic site, prostate-specific antigen level, Gleason score, testosterone level, and use of androgen treatment, were tested for association with the CTC number. The probability of patient survival over time was estimated using the Kaplan-Meier method. Results The baseline CTC numbers were strongly associated with survival ( P