Articular Cartilage Evaluation After TruFit Plug Implantation Analyzed by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC)

Background: Quantitative MRI of articular cartilage has rapidly developed in recent years and provides the clinician with a noninvasive tool to determine the biological consequence of an intervention. Purpose: To evaluate the quality of intra-articular cartilage, using the dGEMRIC scanning technique...

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Bibliographic Details
Published in:The American journal of sports medicine 2013-06, Vol.41 (6), p.1290-1295
Main Authors: Bekkers, Joris E.J., Bartels, Lambertus W., Vincken, Koen L., Dhert, Wouter J.A., Creemers, Laura B., Saris, Daniel B.F.
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Arthroscopy
Cartilage
Cartilage, Articular - surgery
Contrast Media
Femur - surgery
Gadolinium DTPA
Humans
Knee Joint - surgery
Magnetic Resonance Imaging
NMR
Nuclear magnetic resonance
Osteochondritis Dissecans - surgery
Prostheses and Implants - adverse effects
Prosthesis Implantation
Tissues
Transplants & implants
Treatment Outcome
Young Adult
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Summary:Background: Quantitative MRI of articular cartilage has rapidly developed in recent years and provides the clinician with a noninvasive tool to determine the biological consequence of an intervention. Purpose: To evaluate the quality of intra-articular cartilage, using the dGEMRIC scanning technique, 1 year after TruFit implantation. The hypothesis was that implantation of a TruFit plug does not lead to damage at the opposing articular cartilage. Study Design: Case series; Level of evidence, 4. Methods: A total of 13 patients (age, 32 ± 8 years) were evaluated with dGEMRIC at 12 ± 4 months after treatment of an osteochondral lesion by implantation of 1 or multiple TruFit plugs. The dGEMRIC scanning protocol was applied 90 minutes after intravenous Magnevist (0.2 mmol/kg body weight) injection. Different regions of interest (ROIs) were defined: the femur cartilage, cartilage directly surrounding the implanted TruFit plug, the TruFit plug, and the articulating and nonarticulating tibia cartilage. The average dGEMRIC index (T1gd; magnetic resonance imaging relaxation time per ROI) was calculated by a pixel-by-pixel curve fitting using the Levenberg-Marquardt method. Differences between the mean T1gd of the individual ROI for all patients were tested using analysis of variance with post hoc Bonferroni correction. A P value
ISSN:0363-5465
1552-3365
DOI:10.1177/0363546513483536