Renal parenchyma developmental plasticity in mice infected with Schistosoma mansoni, whose mothers were malnourished during lactation

• Published in: Experimental parasitology 2013-07, Vol.134 (3), p.368-373
• Main Authors: Corrêa, Christiane Leal, Moreira, Júlio Cesar Antônio, Vilela, Augusto César Miranda, de Oliveira, Elaine, Moura, Egberto G., Lisboa, Patrícia Cristina, Machado-Silva, José Roberto
• Format: Article
• Language: English
• Subjects: Animals; Animals, Suckling; Bowman space; Caloric Restriction; Developmental plasticity; diet; Diet, Protein-Restricted; Disease Models, Animal; Female; Glomerulus; histology; histopathology; Kidney - growth & development; Kidney - pathology; kidneys; Lactation; Lactation - physiology; malnutrition; Malnutrition - complications; maternal effect; Maternal Nutritional Physiological Phenomena - physiology; Mice; morphometry; mothers; parasitology; parenchyma; Renal parenchyma; Schistosoma mansoni; Schistosomiasis mansoni - pathology
• ISSN: 0014-4894; 1090-2449
• DOI: 10.1016/j.exppara.2013.03.025

•Malnutrition during periods in development may have long-term effects in the adult.•We examine parasitological behavior and histopathological.•For the first time, this study describes the changes of the renal parenchyma.•Induced by postnatal malnutrition associated with infection caused by Schistosoma mansoni. Effects of maternal malnutrition during lactation on the kidneys in mice infected with Schistosoma mansoni. Kidneys from programmed infected mice and their respective controls fed a normal diet (23% protein), a protein-restricted group (PR) (8% protein) and a caloric-restricted group (CR) (according to the PR group intake) evaluated by biometry, morphometry and histopathology. Both PR and CR groups showed a reduction in the number of glomeruli when compared with the control group (CR: −29% vs C; PR: −41% vs C; p