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Renal parenchyma developmental plasticity in mice infected with Schistosoma mansoni, whose mothers were malnourished during lactation
•Malnutrition during periods in development may have long-term effects in the adult.•We examine parasitological behavior and histopathological.•For the first time, this study describes the changes of the renal parenchyma.•Induced by postnatal malnutrition associated with infection caused by Schistos...
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| Published in: | Experimental parasitology 2013-07, Vol.134 (3), p.368-373 |
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| container_end_page | 373 |
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| container_title | Experimental parasitology |
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| creator | Corrêa, Christiane Leal Moreira, Júlio Cesar Antônio Vilela, Augusto César Miranda de Oliveira, Elaine Moura, Egberto G. Lisboa, Patrícia Cristina Machado-Silva, José Roberto |
| description | •Malnutrition during periods in development may have long-term effects in the adult.•We examine parasitological behavior and histopathological.•For the first time, this study describes the changes of the renal parenchyma.•Induced by postnatal malnutrition associated with infection caused by Schistosoma mansoni.
Effects of maternal malnutrition during lactation on the kidneys in mice infected with Schistosoma mansoni. Kidneys from programmed infected mice and their respective controls fed a normal diet (23% protein), a protein-restricted group (PR) (8% protein) and a caloric-restricted group (CR) (according to the PR group intake) evaluated by biometry, morphometry and histopathology. Both PR and CR groups showed a reduction in the number of glomeruli when compared with the control group (CR: −29% vs C; PR: −41% vs C; p |
| doi_str_mv | 10.1016/j.exppara.2013.03.025 |
| format | article |
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Effects of maternal malnutrition during lactation on the kidneys in mice infected with Schistosoma mansoni. Kidneys from programmed infected mice and their respective controls fed a normal diet (23% protein), a protein-restricted group (PR) (8% protein) and a caloric-restricted group (CR) (according to the PR group intake) evaluated by biometry, morphometry and histopathology. Both PR and CR groups showed a reduction in the number of glomeruli when compared with the control group (CR: −29% vs C; PR: −41% vs C; p<0.05) as well as infected mice (ICR: −32% vs IC; IPR: −47% vs IC; p<0.05). Among infected mice, ICR group showed higher kidney weights (+18% vs IC and +12% vs IPR; p<0.01). The ICR and IPR groups showed largest perimeter and area when compared to the corresponding uninfected group (ICR vs CR: +26%; IPR vs PR: +21%, p<0.05) and area (ICR vs CR: +95%; IPR vs PR: +50%, p<0.05). The ICR group showed an increase of within Bowman (CR vs ICR: +56%, p<0.05), whereas Bowman’s space was reduced (PR vs IPR, −61%; p<0.05). Conclude that malnutrition during lactation programmed the metabolic state of the host, resulting in the evolution of the histology of the renal parenchyma.]]></description><identifier>ISSN: 0014-4894</identifier><identifier>EISSN: 1090-2449</identifier><identifier>DOI: 10.1016/j.exppara.2013.03.025</identifier><identifier>PMID: 23567250</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Animals, Suckling ; Bowman space ; Caloric Restriction ; Developmental plasticity ; diet ; Diet, Protein-Restricted ; Disease Models, Animal ; Female ; Glomerulus ; histology ; histopathology ; Kidney - growth & development ; Kidney - pathology ; kidneys ; Lactation ; Lactation - physiology ; malnutrition ; Malnutrition - complications ; maternal effect ; Maternal Nutritional Physiological Phenomena - physiology ; Mice ; morphometry ; mothers ; parasitology ; parenchyma ; Renal parenchyma ; Schistosoma mansoni ; Schistosomiasis mansoni - pathology</subject><ispartof>Experimental parasitology, 2013-07, Vol.134 (3), p.368-373</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c384t-a1f9498214c526df37e2b145199fd431e808207464585237cbf066a5834aaf6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23567250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corrêa, Christiane Leal</creatorcontrib><creatorcontrib>Moreira, Júlio Cesar Antônio</creatorcontrib><creatorcontrib>Vilela, Augusto César Miranda</creatorcontrib><creatorcontrib>de Oliveira, Elaine</creatorcontrib><creatorcontrib>Moura, Egberto G.</creatorcontrib><creatorcontrib>Lisboa, Patrícia Cristina</creatorcontrib><creatorcontrib>Machado-Silva, José Roberto</creatorcontrib><title>Renal parenchyma developmental plasticity in mice infected with Schistosoma mansoni, whose mothers were malnourished during lactation</title><title>Experimental parasitology</title><addtitle>Exp Parasitol</addtitle><description><![CDATA[•Malnutrition during periods in development may have long-term effects in the adult.•We examine parasitological behavior and histopathological.•For the first time, this study describes the changes of the renal parenchyma.•Induced by postnatal malnutrition associated with infection caused by Schistosoma mansoni.
Effects of maternal malnutrition during lactation on the kidneys in mice infected with Schistosoma mansoni. Kidneys from programmed infected mice and their respective controls fed a normal diet (23% protein), a protein-restricted group (PR) (8% protein) and a caloric-restricted group (CR) (according to the PR group intake) evaluated by biometry, morphometry and histopathology. Both PR and CR groups showed a reduction in the number of glomeruli when compared with the control group (CR: −29% vs C; PR: −41% vs C; p<0.05) as well as infected mice (ICR: −32% vs IC; IPR: −47% vs IC; p<0.05). Among infected mice, ICR group showed higher kidney weights (+18% vs IC and +12% vs IPR; p<0.01). The ICR and IPR groups showed largest perimeter and area when compared to the corresponding uninfected group (ICR vs CR: +26%; IPR vs PR: +21%, p<0.05) and area (ICR vs CR: +95%; IPR vs PR: +50%, p<0.05). The ICR group showed an increase of within Bowman (CR vs ICR: +56%, p<0.05), whereas Bowman’s space was reduced (PR vs IPR, −61%; p<0.05). Conclude that malnutrition during lactation programmed the metabolic state of the host, resulting in the evolution of the histology of the renal parenchyma.]]></description><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Bowman space</subject><subject>Caloric Restriction</subject><subject>Developmental plasticity</subject><subject>diet</subject><subject>Diet, Protein-Restricted</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Glomerulus</subject><subject>histology</subject><subject>histopathology</subject><subject>Kidney - growth & development</subject><subject>Kidney - pathology</subject><subject>kidneys</subject><subject>Lactation</subject><subject>Lactation - physiology</subject><subject>malnutrition</subject><subject>Malnutrition - complications</subject><subject>maternal effect</subject><subject>Maternal Nutritional Physiological Phenomena - physiology</subject><subject>Mice</subject><subject>morphometry</subject><subject>mothers</subject><subject>parasitology</subject><subject>parenchyma</subject><subject>Renal parenchyma</subject><subject>Schistosoma mansoni</subject><subject>Schistosomiasis mansoni - pathology</subject><issn>0014-4894</issn><issn>1090-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFUduKFDEQDaK4s6ufoObRh-0x9-48iSzeYEFw3eeQSVdvZ-hO2iSz43yA_22GGX0VCqpCnXMqnIPQK0rWlFD1bruGX8tik10zQvma1GLyCVpRoknDhNBP0YoQKhrRaXGBLnPeEkI6ysRzdMG4VC2TZIV-f4dgJ1yFILjxMFvcwyNMcZkhlONisrl458sB-4Bn76D2AVyBHu99GfGdG30uMcdKnW3IMfhrvB9jBjzHMkLKeA-pPuwU4i75PFZmX4fwgCfrii0-hhfo2WCnDC_P_Qrdf_r44-ZLc_vt89ebD7eN450ojaWDFrpjVDjJVD_wFtiGCkm1HnrBKXSkY6QVSshOMt66zUCUsrLjwtpBOX6F3p50lxR_7iAXM_vsYJpsgLjLhnIliWRCqwqVJ6hLMecEg1mSn206GErMMQGzNecEzDEBQ2oxWXmvzyd2mxn6f6y_llfAmxNgsNHYh-qIub-rCrKm1fJOHyXenxBQrXj0kEx2vsYDvU_VedNH_59P_AH5OaWn</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Corrêa, Christiane Leal</creator><creator>Moreira, Júlio Cesar Antônio</creator><creator>Vilela, Augusto César Miranda</creator><creator>de Oliveira, Elaine</creator><creator>Moura, Egberto G.</creator><creator>Lisboa, Patrícia Cristina</creator><creator>Machado-Silva, José Roberto</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>Renal parenchyma developmental plasticity in mice infected with Schistosoma mansoni, whose mothers were malnourished during lactation</title><author>Corrêa, Christiane Leal ; Moreira, Júlio Cesar Antônio ; Vilela, Augusto César Miranda ; de Oliveira, Elaine ; Moura, Egberto G. ; Lisboa, Patrícia Cristina ; Machado-Silva, José Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-a1f9498214c526df37e2b145199fd431e808207464585237cbf066a5834aaf6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Animals, Suckling</topic><topic>Bowman space</topic><topic>Caloric Restriction</topic><topic>Developmental plasticity</topic><topic>diet</topic><topic>Diet, Protein-Restricted</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Glomerulus</topic><topic>histology</topic><topic>histopathology</topic><topic>Kidney - growth & development</topic><topic>Kidney - pathology</topic><topic>kidneys</topic><topic>Lactation</topic><topic>Lactation - physiology</topic><topic>malnutrition</topic><topic>Malnutrition - complications</topic><topic>maternal effect</topic><topic>Maternal Nutritional Physiological Phenomena - physiology</topic><topic>Mice</topic><topic>morphometry</topic><topic>mothers</topic><topic>parasitology</topic><topic>parenchyma</topic><topic>Renal parenchyma</topic><topic>Schistosoma mansoni</topic><topic>Schistosomiasis mansoni - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corrêa, Christiane Leal</creatorcontrib><creatorcontrib>Moreira, Júlio Cesar Antônio</creatorcontrib><creatorcontrib>Vilela, Augusto César Miranda</creatorcontrib><creatorcontrib>de Oliveira, Elaine</creatorcontrib><creatorcontrib>Moura, Egberto G.</creatorcontrib><creatorcontrib>Lisboa, Patrícia Cristina</creatorcontrib><creatorcontrib>Machado-Silva, José Roberto</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corrêa, Christiane Leal</au><au>Moreira, Júlio Cesar Antônio</au><au>Vilela, Augusto César Miranda</au><au>de Oliveira, Elaine</au><au>Moura, Egberto G.</au><au>Lisboa, Patrícia Cristina</au><au>Machado-Silva, José Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal parenchyma developmental plasticity in mice infected with Schistosoma mansoni, whose mothers were malnourished during lactation</atitle><jtitle>Experimental parasitology</jtitle><addtitle>Exp Parasitol</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>134</volume><issue>3</issue><spage>368</spage><epage>373</epage><pages>368-373</pages><issn>0014-4894</issn><eissn>1090-2449</eissn><abstract><![CDATA[•Malnutrition during periods in development may have long-term effects in the adult.•We examine parasitological behavior and histopathological.•For the first time, this study describes the changes of the renal parenchyma.•Induced by postnatal malnutrition associated with infection caused by Schistosoma mansoni.
Effects of maternal malnutrition during lactation on the kidneys in mice infected with Schistosoma mansoni. Kidneys from programmed infected mice and their respective controls fed a normal diet (23% protein), a protein-restricted group (PR) (8% protein) and a caloric-restricted group (CR) (according to the PR group intake) evaluated by biometry, morphometry and histopathology. Both PR and CR groups showed a reduction in the number of glomeruli when compared with the control group (CR: −29% vs C; PR: −41% vs C; p<0.05) as well as infected mice (ICR: −32% vs IC; IPR: −47% vs IC; p<0.05). Among infected mice, ICR group showed higher kidney weights (+18% vs IC and +12% vs IPR; p<0.01). The ICR and IPR groups showed largest perimeter and area when compared to the corresponding uninfected group (ICR vs CR: +26%; IPR vs PR: +21%, p<0.05) and area (ICR vs CR: +95%; IPR vs PR: +50%, p<0.05). The ICR group showed an increase of within Bowman (CR vs ICR: +56%, p<0.05), whereas Bowman’s space was reduced (PR vs IPR, −61%; p<0.05). Conclude that malnutrition during lactation programmed the metabolic state of the host, resulting in the evolution of the histology of the renal parenchyma.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23567250</pmid><doi>10.1016/j.exppara.2013.03.025</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Animals, Suckling Bowman space Caloric Restriction Developmental plasticity diet Diet, Protein-Restricted Disease Models, Animal Female Glomerulus histology histopathology Kidney - growth & development Kidney - pathology kidneys Lactation Lactation - physiology malnutrition Malnutrition - complications maternal effect Maternal Nutritional Physiological Phenomena - physiology Mice morphometry mothers parasitology parenchyma Renal parenchyma Schistosoma mansoni Schistosomiasis mansoni - pathology |
| title | Renal parenchyma developmental plasticity in mice infected with Schistosoma mansoni, whose mothers were malnourished during lactation |
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