CD95 in cancer: tool or target?

Highlights • CD95 directly activates caspase-independent survival signaling pathways. • CD95 triggers a cell death-inducing inflammatory response. • In vivo data on CD95 contradicts in vitro findings in many mouse models of cancer. • Blocking CD95 signaling in cancer patients is a safe and promising...

Full description

Saved in:
Bibliographic Details
Published in:Trends in molecular medicine 2013-06, Vol.19 (6), p.329-335
Main Authors: Martin-Villalba, Ana, Llorens-Bobadilla, Enric, Wollny, Damian
Format: Article
Language:English
Subjects:
Animals
apoptosis
cancer therapy
CD95
clinical studies
FAS
fas Receptor - genetics
fas Receptor - metabolism
Humans
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Pathology
Signal Transduction
tumorigenesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • CD95 directly activates caspase-independent survival signaling pathways. • CD95 triggers a cell death-inducing inflammatory response. • In vivo data on CD95 contradicts in vitro findings in many mouse models of cancer. • Blocking CD95 signaling in cancer patients is a safe and promising treatment option.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2013.03.002