Thermally activated transport of physiologically active compounds

This survey concerns the potential inherent in the conformational transition of macromolecules that occurs at an LSCT for the targeted transport of physiologically active compounds linked to these macromolecules. Methods for controlling the LSCT of the polymeric carrier are discussed, and relationsh...

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Bibliographic Details
Published in:Polymer science. Series A, Chemistry, physics Chemistry, physics, 2009-12, Vol.51 (11-12), p.1204-1209
Main Authors: Valuev, L. I., Valuev, I. L., Platé, N. A.
Format: Article
Language:English
Subjects:
Activated
Active control
Biological
Carriers
Chemistry
Chemistry and Materials Science
Conservation
Macromolecules
Organisms
Polymer Sciences
Transport
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Summary:This survey concerns the potential inherent in the conformational transition of macromolecules that occurs at an LSCT for the targeted transport of physiologically active compounds linked to these macromolecules. Methods for controlling the LSCT of the polymeric carrier are discussed, and relationships between the biological activity of the compounds being transported and their structure and the structure of the polymeric carrier are examined. Approaches ensuring conservation of biological activity via the repeated transition through LCST and providing removal of all components of the system from a living organism are considered.
ISSN:0965-545X
1555-6107
DOI:10.1134/S0965545X09110042