Hybrid hydrogels produced by ionizing radiation technique

• Published in: Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2012-09, Vol.81 (9), p.1471-1474
• Main Authors: Oliveira, M.J.A., Amato, V.S., Lugão, A.B., Parra, D.F.
• Format: Article
• Language: English
• Subjects: Biocompatibility; Clay; Hydrogel; Hydrogels; Matrices; Nanocomposite; Nanocomposites; Nanomaterials; Nanostructure; PVAl; Swelling; Toxicity
• ISSN: 0969-806X; 1879-0895
• DOI: 10.1016/j.radphyschem.2012.02.004

The interest in biocompatible hydrogels with particular properties has increased considerably in recent years due to their versatile applications in biomedicine, biotechnology, pharmacy, agriculture and controlled release of drugs. The use of hydrogels matrices for particular drug-release applications has been investigated with the synthesis of modified polymeric hydrogel of PVAl and 0.5, 1.0, 1.5% nano-clay. They were processed using gamma radiation from Cobalt-60 source at 25kGy dose. The characterization of the hydrogels was conducted and toxicity was evaluated. The dried hydrogel was analyzed for thermogravimetry analysis (TGA), infrared spectroscopy (FTIR) and swelling in solutions of different pH. The membranes have no toxicity. The nano-clay influences directly the equilibrium swelling. ► Chemical interaction is observed when nanoclay is irradiated in PVAl hybrid hydrogels. ► Osmotic pressure within network promotes the rehydration capacity of the membranes. ► This effect is an important characteristic for hydrogels drug delivery systems.