Li-gazing at the crest: Modulation of the neural crest by the ubiquitin pathway

Neural crest cells are a transient population of stem cells that give rise to a diverse range of cell types during embryonic development. Through gain-of-function and loss-of-function studies in several model organisms many key signalling pathways and cell-type specific transcription factors essenti...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2013-06, Vol.45 (6), p.1087-1091
Main Authors: Wiszniak, Sophie, Lumb, Rachael, Kabbara, Samuela, Scherer, Michaela, Schwarz, Quenten
Format: Article
Language:English
Subjects:
Animals
Embryonic Development - physiology
Gene Expression Regulation, Developmental - physiology
Humans
Neural crest
Neural Crest - cytology
Neural Crest - embryology
Signal Transduction - physiology
Stem cell
Transcription Factors - metabolism
Ubiquitin
Ubiquitin - metabolism
Ubiquitination - physiology
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Summary:Neural crest cells are a transient population of stem cells that give rise to a diverse range of cell types during embryonic development. Through gain-of-function and loss-of-function studies in several model organisms many key signalling pathways and cell-type specific transcription factors essential for neural crest cell development have been identified. However, the role of post-translational regulation remains largely unexplored. Here we review this cell type with a foray into the known and potential roles of the ubiquitination pathway in key signalling events during neural crest cell development.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2013.02.014