The role of DNA damage and repair in aging through the prism of Koch-like criteria

Highlights ► Accumulation of DNA damage/mutations has long been suggested to play a causal role in aging. ► Four logical “Koch-like” criteria are proposed for evaluating this hypothesis. ► They presume some quantitative relationship between the levels of DNA damage and aging rate. ► The analysis sho...

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Bibliographic Details
Published in:Ageing research reviews 2013-03, Vol.12 (2), p.661-684
Main Authors: Moskalev, Alexey A, Shaposhnikov, Mikhail V, Plyusnina, Ekaterina N, Zhavoronkov, Alex, Budovsky, Arie, Yanai, Hagai, Fraifeld, Vadim E
Format: Article
Language:English
Subjects:
Aging - genetics
Aging, Premature - genetics
Animals
Cellular Senescence - genetics
Clonal Evolution
DNA Damage
DNA Repair
Humans
Internal Medicine
Longevity - genetics
Models, Genetic
Mutagenesis - drug effects
Mutagens - pharmacology
Mutation
Neurology
Stem Cells - physiology
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Summary:Highlights ► Accumulation of DNA damage/mutations has long been suggested to play a causal role in aging. ► Four logical “Koch-like” criteria are proposed for evaluating this hypothesis. ► They presume some quantitative relationship between the levels of DNA damage and aging rate. ► The analysis showed that many gaps should still be filled in order to reach a clear-cut conclusion.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2012.02.001