A squaraine-based red emission off-on chemosensor for biothiols and its application in living cells imaging

A new probe based on the squaraine skeleton with a 2,4-dinitrobenzenesulfonyl unit is reported as a fluorescent probe for biothiol. It shows turn-on properties with red emission towards biothiols in acetonitrile-PBS buffer (1 : 9, v/v) solution, and its properties of rapid response, high selectivity...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2013-07, Vol.11 (25), p.4258-4264
Main Authors: Liu, Xiao-Dong, Sun, Ru, Ge, Jian-Feng, Xu, Yu-Jie, Xu, Ying, Lu, Jian-Mei
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Cyclobutanes - chemistry
Fluorescent Dyes - chemistry
Humans
Microscopy, Confocal
Molecular Imaging
Phenols - chemistry
Spectrometry, Fluorescence
Sulfhydryl Compounds - analysis
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Summary:A new probe based on the squaraine skeleton with a 2,4-dinitrobenzenesulfonyl unit is reported as a fluorescent probe for biothiol. It shows turn-on properties with red emission towards biothiols in acetonitrile-PBS buffer (1 : 9, v/v) solution, and its properties of rapid response, high selectivity and high sensitivity make it a potential probe with real applications. Moreover, the in vitro assays show that the probe can be used in fluorescence imaging for the detection of intracellular biothiol levels.
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob40502h