A squaraine-based red emission off-on chemosensor for biothiols and its application in living cells imaging

A new probe based on the squaraine skeleton with a 2,4-dinitrobenzenesulfonyl unit is reported as a fluorescent probe for biothiol. It shows turn-on properties with red emission towards biothiols in acetonitrile-PBS buffer (1 : 9, v/v) solution, and its properties of rapid response, high selectivity...

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Published in:Organic & biomolecular chemistry 2013-07, Vol.11 (25), p.4258-4264
Main Authors: Liu, Xiao-Dong, Sun, Ru, Ge, Jian-Feng, Xu, Yu-Jie, Xu, Ying, Lu, Jian-Mei
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Cyclobutanes - chemistry
Fluorescent Dyes - chemistry
Humans
Microscopy, Confocal
Molecular Imaging
Phenols - chemistry
Spectrometry, Fluorescence
Sulfhydryl Compounds - analysis
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cited_by cdi_FETCH-LOGICAL-c287t-78ae3b29abd3883f88d3fb2b75b0f827810b10e7694948161f4283f42d77b6873
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container_title Organic & biomolecular chemistry
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creator Liu, Xiao-Dong
Sun, Ru
Ge, Jian-Feng
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description A new probe based on the squaraine skeleton with a 2,4-dinitrobenzenesulfonyl unit is reported as a fluorescent probe for biothiol. It shows turn-on properties with red emission towards biothiols in acetonitrile-PBS buffer (1 : 9, v/v) solution, and its properties of rapid response, high selectivity and high sensitivity make it a potential probe with real applications. Moreover, the in vitro assays show that the probe can be used in fluorescence imaging for the detection of intracellular biothiol levels.
doi_str_mv 10.1039/c3ob40502h
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source Royal Society of Chemistry
subjects Cell Line, Tumor
Cyclobutanes - chemistry
Fluorescent Dyes - chemistry
Humans
Microscopy, Confocal
Molecular Imaging
Phenols - chemistry
Spectrometry, Fluorescence
Sulfhydryl Compounds - analysis
title A squaraine-based red emission off-on chemosensor for biothiols and its application in living cells imaging
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