Hardness and Density Distributions of Pharmaceutical Tablets Measured by Terahertz Pulsed Imaging

We present terahertz pulsed imaging (TPI) as a novel tool to quantify the hardness and surface density distribution of pharmaceutical tablets. Good agreement between the surface refractive index (SRI) measured by TPI and the crushing force measured from diametral compression tests was found using a...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2013-07, Vol.102 (7), p.2179-2186
Main Authors: May, Robert K., Su, Ke, Han, Lianghao, Zhong, Shuncong, Elliott, James A., Gladden, Lynn F., Evans, Mike, Shen, Yaochun, Zeitler, J. Axel
Format: Article
Language:English
Subjects:
compaction
density distribution
diametral compression test (DCT)
Drug Compounding
Finite Element Analysis
finite element analysis (FEA)
Hardness
imaging methods
Mechanical properties
processing
Refractometry
Surface Properties
tablet hardness testing
tableting
Tablets - chemistry
Terahertz Imaging
terahertz pulsed imaging (TPI)
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Summary:We present terahertz pulsed imaging (TPI) as a novel tool to quantify the hardness and surface density distribution of pharmaceutical tablets. Good agreement between the surface refractive index (SRI) measured by TPI and the crushing force measured from diametral compression tests was found using a set of tablets that were compacted at various compression forces. We also found a strong correlation between TPI results and tablet bulk density, and how these relate to tablet hardness. Numerical simulations of tablet surface density distribution by finite element analysis exhibit excellent agreement with the TPI measured SRI maps. These results show that TPI has an advantage over traditional diametral compression and is more suitable for nondestructive hardness and density distribution monitoring and control of pharmaceutical manufacturing processes. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2179–2186, 2013
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.23560