The expression of IL-6 and STAT3 might predict progression and unfavorable prognosis in Wilms’ tumor

• Published in: Biochemical and biophysical research communications 2013-06, Vol.435 (3), p.408-413
• Main Authors: Zhang, Li-Juan, Liu, Wei, Gao, Ying-Mao, Qin, Ye-Jun, Wu, Rong-De
• Format: Article
• Language: English
• Subjects: Child; Child, Preschool; Disease Progression; Female; Humans; IL-6; Infant; Interleukin-6 - biosynthesis; Interleukin-6 - genetics; Invasion; Kidney Neoplasms - genetics; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Male; Metastasis; Neoplasm Invasiveness - genetics; Predictive Value of Tests; Prognosis; Progression; Retrospective Studies; STAT3; STAT3 Transcription Factor - biosynthesis; STAT3 Transcription Factor - genetics; Wilms Tumor - genetics; Wilms Tumor - pathology; Wilms Tumor - secondary; Wilms’ tumor
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2013.04.102

•IL-6/STAT3 expression was associated with invasion/metastasis in Wilms’ tumor.•IL-6/STAT3 showed a concordance expression between primary WT and matched Inv/Meta.•Patients with either IL-6 or STAT3 expression had shorter DFS than those without.•Patients with IL-6 had shorter OS than those without. To investigate the expression profiles of IL-6 and STAT3 in Wilms’ tumor (WT) and their relationship with disease progression. Immunohistochemistry was used to examine IL-6 and STAT3 expression in 58 primary tumors and 18 invasive/metastatic ones. Positive expression rate of IL-6/STAT3 was 39.7% (23/58)/29.3% (17/58) in primary WT tissues, while 61.1% (11/18)/33.3% (6/18) in associated invasive/metastatic tissues. The expression rate of IL-6 and STAT3 was higher in primary WT tumors of invasive/metastatic group than that of non-invasive/metastatic group (P=0.033; P=0.012). There was a positive correlation between IL-6 and STAT3 expression in 76 WT tissues (P