Warthin's tumor associated with IgG4-related disease

Abstract Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. Several inflammatory conditions associated with IgG4-RD have been reported. Warthin's tumor is a benign parotid g...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2013-10, Vol.40 (5), p.514-517
Main Authors: Aga, Mitsuharu, Kondo, Satoru, Yamada, Kazunori, Sawada-Kitamura, Seiko, Yagi-Nakanishi, Sayaka, Endo, Kazuhira, Wakisaka, Naohiro, Murono, Shigeyuki, Kawano, Mitsuhiro, Yoshizaki, Tomokazu
Format: Article
Language:English
Subjects:
Adenolymphoma - complications
Adenolymphoma - immunology
Adenolymphoma - pathology
Aged
Aortic Aneurysm, Abdominal - complications
Aortic Aneurysm, Abdominal - immunology
Autoimmune Diseases - complications
Autoimmune Diseases - immunology
Autoimmune pancreatitis
Humans
Hypergammaglobulinemia - complications
Hypergammaglobulinemia - immunology
IgG4-related disease
Immunoglobulin G
Inflammatory abdominal aortic aneurysm
Male
Neoplasm Recurrence, Local - complications
Neoplasm Recurrence, Local - immunology
Neoplasm Recurrence, Local - pathology
Otolaryngology
Pancreatitis - complications
Pancreatitis - immunology
Parotid gland tumor
Parotid Neoplasms - complications
Parotid Neoplasms - immunology
Parotid Neoplasms - pathology
Warthin's tumor
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Summary:Abstract Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. Several inflammatory conditions associated with IgG4-RD have been reported. Warthin's tumor is a benign parotid gland tumor consisting of oncocytic epithelial cells and lymphoid stroma containing lymphoid follicles with reactive germinal centers. This is the first report describing a case of Warthin's tumor with possible involvement of IgG4-RD. The patient was a 71-year-old man presenting with swollen right parotid and bilateral submandibular glands. He had a history of a Warthin's tumor of the left parotid gland, autoimmune pancreatitis, and an inflammatory abdominal aortic aneurysm. Laboratory tests revealed a high serum IgG4 level. Histological examination of the resected parotid gland showed a Warthin's tumor and a nodule showing severe lymphocytic infiltration containing many IgG4-positive plasma cells. This case shows the possible involvement of Warthin's tumor with IgG4-RD.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2012.11.005