Predictors of Health-related Quality of Life and Adjustment to Prostate Cancer During Active Surveillance

Abstract Background Active surveillance (AS) is emerging as an alternative approach to limit the risk of overtreatment and impairment of quality of life (QoL) in patients with low-risk localised prostate cancer. Although most patients report high levels of QoL, some men may be distressed by the idea...

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Bibliographic Details
Published in:European urology 2013-07, Vol.64 (1), p.30-36
Main Authors: Bellardita, Lara, Rancati, Tiziana, Alvisi, Maria Francesca, Villani, Daniela, Magnani, Tiziana, Marenghi, Cristina, Nicolai, Nicola, Procopio, Giuseppe, Villa, Sergio, Salvioni, Roberto, Valdagni, Riccardo
Format: Article
Language:English
Subjects:
Active surveillance
Adaptation, Psychological
Adjustment to cancer
Aged
Biological and medical sciences
Biopsy
Coping
Cost of Illness
Gynecology. Andrology. Obstetrics
Humans
Logistic Models
Male
Male genital diseases
Marital Status
Medical sciences
Mental Health
Middle Aged
Multivariate Analysis
Nephrology. Urinary tract diseases
Odds Ratio
Prostate cancer
Prostatic Neoplasms - pathology
Prostatic Neoplasms - psychology
Prostatic Neoplasms - therapy
Quality of Life
Risk Factors
Social Support
Stress, Psychological - diagnosis
Stress, Psychological - etiology
Stress, Psychological - psychology
Surveys and Questionnaires
Time Factors
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
Urology
Watchful Waiting
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Summary:Abstract Background Active surveillance (AS) is emerging as an alternative approach to limit the risk of overtreatment and impairment of quality of life (QoL) in patients with low-risk localised prostate cancer. Although most patients report high levels of QoL, some men may be distressed by the idea of living with untreated cancer. Objective To identify factors associated with poor QoL during AS. Design, setting, and participants Between September 2007 and March 2012, 103 patients participated in the Prostate Cancer Research International Active Surveillance (PRIAS) QoL study. Mental health (Symptom Checklist-90), demographic, clinical, and decisional data were assessed at entrance in AS. Health-related QoL (HRQoL) Functional Assessment of Cancer Therapy-Prostate version and Mini-Mental Adjustment to Cancer outcomes were assessed after 10 mo of AS. Outcome measurements and statistical analysis Multivariate logistic regression models were used to identify predictors of low (
ISSN:0302-2838
1873-7560
DOI:10.1016/j.eururo.2013.01.009