Evidence for impaired visual prediction error in schizophrenia

Abstract Background Mismatch negativity (MMN) is regarded a prediction error signal that is deficient in schizophrenia in the auditory modality. If, however, MMN reflects a general computational signal of the cortex, then MMN should be also deficient in the visual modality in schizophrenia patients....

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Bibliographic Details
Published in:Schizophrenia research 2013-07, Vol.147 (2), p.326-330
Main Authors: Neuhaus, Andres H, Brandt, Emily S.L, Goldberg, Terry E, Bates, John A, Malhotra, Anil K
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain Mapping
Case-Control Studies
Contingent Negative Variation - physiology
Electroencephalography
Event-related potential
Female
Hallucinations - diagnosis
Hallucinations - etiology
Humans
Male
Medical sciences
Middle Aged
Mismatch negativity
Oddball
Photic Stimulation
Prediction error
Predictive coding
Predictive Value of Tests
Psychiatric Status Rating Scales
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reaction Time - physiology
Schizophrenia
Schizophrenia - complications
Young Adult
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Summary:Abstract Background Mismatch negativity (MMN) is regarded a prediction error signal that is deficient in schizophrenia in the auditory modality. If, however, MMN reflects a general computational signal of the cortex, then MMN should be also deficient in the visual modality in schizophrenia patients. Methods Twenty-two schizophrenia patients and 24 matched healthy controls finished a visual oddball task while high-density electroencephalogram was recorded. Visual mismatch negativity was computed as a surrogate marker of prediction error. Results Visual MMN, as measured over posterior extra-striate cortical areas, was significantly reduced in schizophrenia at about 300 ms post stimulus. Standardized mean difference was − .98, corresponding to a large effect size. Conclusions A posterior visual MMN deficit in schizophrenia is demonstrated for the first time. Our results tentatively suggest a supra-modal MMN deficit in schizophrenia and thus argue in favor of reduced prediction error estimation in schizophrenia.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2013.04.004