Incidence of second hip fracture and compliant use of bisphosphonate

Summary We determined the incidence of second hip fracture and evaluated whether compliant users of bisphosphonate had a lower incidence of second hip fracture after prior hip fracture. Introduction Bisphosphonate has been used to prevent osteoporotic fracture and is recommended for the secondary pr...

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Bibliographic Details
Published in:Osteoporosis international 2013-07, Vol.24 (7), p.2099-2104
Main Authors: Lee, Y.-K., Ha, Y.-C., Yoon, B.-H., Koo, K.-H.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Bone Density Conservation Agents - therapeutic use
Compliance
Diphosphonates - therapeutic use
Drug Evaluation - methods
Drug therapy
Endocrinology
Female
Fractures
Hip Fractures - etiology
Hip Fractures - prevention & control
Hip joint
Humans
Male
Medication Adherence
Medicine
Medicine & Public Health
Middle Aged
Original Article
Orthopedics
Osteoporosis - complications
Osteoporosis - drug therapy
Osteoporotic Fractures - prevention & control
Preventive medicine
Republic of Korea
Retrospective Studies
Rheumatology
Secondary Prevention
Survival Analysis
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Summary:Summary We determined the incidence of second hip fracture and evaluated whether compliant users of bisphosphonate had a lower incidence of second hip fracture after prior hip fracture. Introduction Bisphosphonate has been used to prevent osteoporotic fracture and is recommended for the secondary prevention after hip fracture. However, little is known regarding secondary prevention after first hip fracture. Our purpose was to determine the incidence of second hip fracture and to evaluate whether compliant use of bisphosphonate can reduce the risk of second hip fracture. Methods Eight hundred twenty-six patients who sustained the first hip fracture from May 2003 to October 2011 were retrospectively evaluated. The incidence of second hip fracture was compared between compliant users of bisphosphonate and nonusers. Results Seventy-one (8.6 %) patients suffered a second hip fracture at mean 30.0 months (SD 24.6, range 1 to 90 months) after the initial hip fracture. The cumulative incidence of second hip fracture was 5.1 % (42/826) at 2 years and 8.6 % (71/826) at 8 years. The incidence of second hip fracture was 4.2 % (12/283) in compliant users and 10.9 % (59/543) in nonusers ( p  = 0.001). Conclusions Compliant use of bisphosphonate is effective in the prevention of second hip fractures.
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-012-2250-0