Reduced anticipatory dopamine responses to food in rats exposed to high fat during early development

We have previously demonstrated that exposure to high fat (HF) during early development alters the presynaptic regulation of mesolimbic dopamine (DA), and increases incentive motivation for HF food rewards. The goal of the present experiments was to examine the long-term consequences of early exposu...

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Bibliographic Details
Published in:International Journal of Obesity 2013-06, Vol.37 (6), p.885-888
Main Authors: Naef, L, Moquin, L, Gratton, A, Walker, C-D
Format: Article
Language:English
Subjects:
631/378/1488
692/699/1702/393
Animals
Biological and medical sciences
Classical conditioning
Diet
Diet, High-Fat
Disease Susceptibility
Dopamine
Dopamine - metabolism
Electrodes
Epidemiology
Exposure
Feeding Behavior
Female
Food
Health aspects
Health Promotion and Disease Prevention
Humans
Internal Medicine
Male
Maternal Nutritional Physiological Phenomena
Medical sciences
Medicine
Medicine & Public Health
Mental health
Metabolic Diseases
Neurosciences
Obesity
Obesity - metabolism
Obesity - physiopathology
Offspring
Oxidation
Physical Conditioning, Animal
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Prenatal Exposure Delayed Effects - physiopathology
Public Health
Rats
Rats, Sprague-Dawley
Reward
short-communication
Synaptic Transmission
Variance analysis
Voltammetry
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Summary:We have previously demonstrated that exposure to high fat (HF) during early development alters the presynaptic regulation of mesolimbic dopamine (DA), and increases incentive motivation for HF food rewards. The goal of the present experiments was to examine the long-term consequences of early exposure to HF on anticipatory and consumatory nucleus accumbens (NAc) DA responses to HF food rewards. Mothers were maintained on a HF (30% fat) or control diet (CD; 5% fat) from gestation day 13 to postnatal day 22 when offspring from both diet groups were weaned and maintained on the CD until adulthood. In vivo NAc DA responses to food anticipation and consumption were measured in a Pavlovian conditioning paradigm using voltammetry in freely moving rats. HF-exposed offspring displayed reduced NAc DA responses to a tone previously paired with the delivery of HF food rewards. In an unconditioned protocol, consumatory NAc DA responses could be isolated, and were similar in HF and control offspring. These data demonstrate that exposure to HF through maternal diet during early development might program behavioral and functional responses associated with mesolimbic DA neurotransmission, thus leading to an increased HF feeding and obesity.
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2012.153