Metabolic interactions: lead, calcium, and iron [Nutritionally required metals, toxicity]

Certain of the physiologic mechanisms that control calcium metabolism have also been shown experimentally to alter absorption and tissue distribution of lead in experimental animals. Interactions between lead and iron are far less well understood. Much of what is known was learned from studies of lo...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1980, Vol.355, p.285
Main Authors: Mahaffey, K R, Rader, J I
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - drug effects
Bone and Bones - metabolism
Calcium - deficiency
Calcium - metabolism
Calcium - pharmacology
Child
Humans
Intestinal Absorption - drug effects
Iron - metabolism
Kidney - metabolism
Lead - metabolism
Lead - pharmacology
Lead Poisoning - metabolism
Nutritional Physiological Phenomena
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Summary:Certain of the physiologic mechanisms that control calcium metabolism have also been shown experimentally to alter absorption and tissue distribution of lead in experimental animals. Interactions between lead and iron are far less well understood. Much of what is known was learned from studies of low-income urban children, in whom iron deficiency and lead toxicity are both prevalent. Iron deficiency results in increased absorption and tissue retention of lead, but the metabolic mechanisms involved are not nearly as well understood as those for calcium.
ISSN:0077-8923
1749-6632