Carcinogenicity of Butylated Hydroxyanisole in F344 Rats

Butylated hydroxyanisole (BHA) was added at levels of 0.5 and 2.0% to the diet of inbred F344 rats for 2 years. The higher dose of BHA induced a significant increase in the incidence of papilloma and squamous cell carcinoma in both sexes. Both the higher and lower doses increased the incidences of h...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1983-02, Vol.70 (2), p.343-352
Main Authors: Ito, Nobuyuki, Fukushima, Shoji, Haqlwara, Akihiro, Shibata, Michiko, Ogiso, Tadashi
Format: Article
Language:English
Subjects:
Animals
Anisoles - toxicity
Blood Cell Count
Body Weight
Butylated Hydroxyanisole - toxicity
Carcinoma, Squamous Cell - chemically induced
Carcinoma, Squamous Cell - pathology
Diet
Dose-Response Relationship, Drug
Female
Male
Neoplasm Metastasis
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - pathology
Papilloma - chemically induced
Papilloma - pathology
Rats
Rats, Inbred F344
Rats, Inbred Strains
Stomach Neoplasms - chemically induced
Stomach Neoplasms - pathology
Time Factors
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Summary:Butylated hydroxyanisole (BHA) was added at levels of 0.5 and 2.0% to the diet of inbred F344 rats for 2 years. The higher dose of BHA induced a significant increase in the incidence of papilloma and squamous cell carcinoma in both sexes. Both the higher and lower doses increased the incidences of hyperplasia of the forestomach, considered to be associated with neoplasias. The incidences of these neoplastic changes were dose-dependent. Neoplastic changes in other organs were not increased significantly by BHA. These results show that BHA is carcinogenic in the forestomach of F344 rats.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/70.2.343