Neuroblastoma involvement of the falx cerebri

Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare. The falx is derived from the neural crest and thus may be a location for primary neuroblastoma. Its propensity for metastasis is unknown. Management of neuroblastoma in this location is potentially challengi...

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Bibliographic Details
Published in:Pediatric blood & cancer 2009-12, Vol.53 (7), p.1337-1339
Main Authors: Quackenbush, Katherine Elizabeth, Luna-Fineman, Sandra, Magee, James Fergall, Gundogan, Munire, Golobi, Mahin, Irie, Takeshi, Fernandez, Conrad Vincent
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - drug therapy
Adrenal Gland Neoplasms - pathology
Adrenal Gland Neoplasms - surgery
Adrenalectomy
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carboplatin - administration & dosage
Cell Lineage
Cyclophosphamide - administration & dosage
Doxorubicin - administration & dosage
Dura Mater - pathology
Etoposide - administration & dosage
falx cerebri
Female
Humans
Infant
Infant, Newborn
Male
Meningeal Neoplasms - drug therapy
Meningeal Neoplasms - secondary
metastases
Microphthalmia-Associated Transcription Factor - genetics
Neoplasm Staging
Neural Crest
neuroblastoma
Neuroblastoma - drug therapy
Neuroblastoma - genetics
Neuroblastoma - pathology
Neuroblastoma - secondary
Neuroblastoma - surgery
Pulmonary Veins - abnormalities
Remission Induction
Skin Neoplasms - drug therapy
Skin Neoplasms - secondary
stage 4S
Waardenburg Syndrome - complications
Waardenburg Syndrome - genetics
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Description
Summary:Involvement of the falx cerebri in infants with stage 4 neuroblastoma is thought to be rare. The falx is derived from the neural crest and thus may be a location for primary neuroblastoma. Its propensity for metastasis is unknown. Management of neuroblastoma in this location is potentially challenging. We describe two children less than 18 months of age who were successfully managed with chemotherapy alone (without radiation or surgery) for falx involvement with neuroblastoma. Pediatr Blood Cancer 2009; 53:1337–1339. © 2009 Wiley‐Liss, Inc.
ISSN:1545-5009
1545-5017
1545-5017
DOI:10.1002/pbc.22192