Histone modifications and mitosis: countermarks, landmarks, and bookmarks

The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few year...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cell biology 2013-04, Vol.23 (4), p.175-184
Main Authors: Wang, Fangwei, Higgins, Jonathan M.G
Format: Article
Language:English
Subjects:
acetylation
Animals
centromere
Chromatin - metabolism
histone
Histones - metabolism
Humans
methylation
Mitosis
Models, Biological
Pathology
phosphorylation
Protein Processing, Post-Translational
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c437t-fa48f6096b4ed18bac0f548f0cbfd9ae0aa1929d51bff11a81da2ffe9db34ead3
cites cdi_FETCH-LOGICAL-c437t-fa48f6096b4ed18bac0f548f0cbfd9ae0aa1929d51bff11a81da2ffe9db34ead3
container_end_page 184
container_issue 4
container_start_page 175
container_title Trends in cell biology
container_volume 23
creator Wang, Fangwei
Higgins, Jonathan M.G
description The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to provide an integrated view of how histone modifications act as ‘countermarks’, ‘landmarks’, and ‘bookmarks’ to displace, recruit, and ‘remember’ the location of regulatory proteins during and shortly after mitosis. These capabilities allow histone marks to help downregulate interphase functions such as transcription during mitosis, to facilitate chromatin events required to accomplish chromosome segregation, and to contribute to the maintenance of epigenetic states through mitosis.
doi_str_mv 10.1016/j.tcb.2012.11.005
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1367484356</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S096289241200219X</els_id><sourcerecordid>1367484356</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-fa48f6096b4ed18bac0f548f0cbfd9ae0aa1929d51bff11a81da2ffe9db34ead3</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhS1ERYeBH8AGZcmCpPfanjxAqoQqoJUqdVGQ2FmOfS15JomLnSD13-MwAwsWiJVf5xxdf4exVwgVAtYX-2o2fcUBeYVYAeyesA22TVcKaNunbANdzcu24_KcPU9pDwANR_GMnXPBZS0FbNjNtU9zmKgYg_XOGz37MKVCT7YY_RyST-8KE5ZppjjqeEhviyG_nbarqg_h8Ov4gp05PSR6eVq37Ounj1-ursvbu883Vx9uSyNFM5dOy9bVebJeksW21wbcLl-B6Z3tNIHW2PHO7rB3DlG3aDV3jjrbC0naii17c8x9iOH7QmlWo0-GhjwXhSUpFHUjWyl29X9IOW8Er7N6y_AoNTGkFMmph-jzvx4Vglphq73KsNUKWyGqDDt7Xp_il34k-8fxm24WvD8KKPP44SmqZDxNhqyPZGZlg_9n_OVfbjP4KVc0HOiR0j4sccqgFarEFaj7te21bOQAHLtv4id7sqVp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1322732684</pqid></control><display><type>article</type><title>Histone modifications and mitosis: countermarks, landmarks, and bookmarks</title><source>ScienceDirect Freedom Collection</source><creator>Wang, Fangwei ; Higgins, Jonathan M.G</creator><creatorcontrib>Wang, Fangwei ; Higgins, Jonathan M.G</creatorcontrib><description>The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to provide an integrated view of how histone modifications act as ‘countermarks’, ‘landmarks’, and ‘bookmarks’ to displace, recruit, and ‘remember’ the location of regulatory proteins during and shortly after mitosis. These capabilities allow histone marks to help downregulate interphase functions such as transcription during mitosis, to facilitate chromatin events required to accomplish chromosome segregation, and to contribute to the maintenance of epigenetic states through mitosis.</description><identifier>ISSN: 0962-8924</identifier><identifier>EISSN: 1879-3088</identifier><identifier>DOI: 10.1016/j.tcb.2012.11.005</identifier><identifier>PMID: 23246430</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>acetylation ; Animals ; centromere ; Chromatin - metabolism ; histone ; Histones - metabolism ; Humans ; methylation ; Mitosis ; Models, Biological ; Pathology ; phosphorylation ; Protein Processing, Post-Translational</subject><ispartof>Trends in cell biology, 2013-04, Vol.23 (4), p.175-184</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-fa48f6096b4ed18bac0f548f0cbfd9ae0aa1929d51bff11a81da2ffe9db34ead3</citedby><cites>FETCH-LOGICAL-c437t-fa48f6096b4ed18bac0f548f0cbfd9ae0aa1929d51bff11a81da2ffe9db34ead3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23246430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Fangwei</creatorcontrib><creatorcontrib>Higgins, Jonathan M.G</creatorcontrib><title>Histone modifications and mitosis: countermarks, landmarks, and bookmarks</title><title>Trends in cell biology</title><addtitle>Trends Cell Biol</addtitle><description>The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to provide an integrated view of how histone modifications act as ‘countermarks’, ‘landmarks’, and ‘bookmarks’ to displace, recruit, and ‘remember’ the location of regulatory proteins during and shortly after mitosis. These capabilities allow histone marks to help downregulate interphase functions such as transcription during mitosis, to facilitate chromatin events required to accomplish chromosome segregation, and to contribute to the maintenance of epigenetic states through mitosis.</description><subject>acetylation</subject><subject>Animals</subject><subject>centromere</subject><subject>Chromatin - metabolism</subject><subject>histone</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>methylation</subject><subject>Mitosis</subject><subject>Models, Biological</subject><subject>Pathology</subject><subject>phosphorylation</subject><subject>Protein Processing, Post-Translational</subject><issn>0962-8924</issn><issn>1879-3088</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1DAUhS1ERYeBH8AGZcmCpPfanjxAqoQqoJUqdVGQ2FmOfS15JomLnSD13-MwAwsWiJVf5xxdf4exVwgVAtYX-2o2fcUBeYVYAeyesA22TVcKaNunbANdzcu24_KcPU9pDwANR_GMnXPBZS0FbNjNtU9zmKgYg_XOGz37MKVCT7YY_RyST-8KE5ZppjjqeEhviyG_nbarqg_h8Ov4gp05PSR6eVq37Ounj1-ursvbu883Vx9uSyNFM5dOy9bVebJeksW21wbcLl-B6Z3tNIHW2PHO7rB3DlG3aDV3jjrbC0naii17c8x9iOH7QmlWo0-GhjwXhSUpFHUjWyl29X9IOW8Er7N6y_AoNTGkFMmph-jzvx4Vglphq73KsNUKWyGqDDt7Xp_il34k-8fxm24WvD8KKPP44SmqZDxNhqyPZGZlg_9n_OVfbjP4KVc0HOiR0j4sccqgFarEFaj7te21bOQAHLtv4id7sqVp</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Wang, Fangwei</creator><creator>Higgins, Jonathan M.G</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130401</creationdate><title>Histone modifications and mitosis: countermarks, landmarks, and bookmarks</title><author>Wang, Fangwei ; Higgins, Jonathan M.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-fa48f6096b4ed18bac0f548f0cbfd9ae0aa1929d51bff11a81da2ffe9db34ead3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>acetylation</topic><topic>Animals</topic><topic>centromere</topic><topic>Chromatin - metabolism</topic><topic>histone</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>methylation</topic><topic>Mitosis</topic><topic>Models, Biological</topic><topic>Pathology</topic><topic>phosphorylation</topic><topic>Protein Processing, Post-Translational</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Fangwei</creatorcontrib><creatorcontrib>Higgins, Jonathan M.G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Trends in cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Fangwei</au><au>Higgins, Jonathan M.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histone modifications and mitosis: countermarks, landmarks, and bookmarks</atitle><jtitle>Trends in cell biology</jtitle><addtitle>Trends Cell Biol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>23</volume><issue>4</issue><spage>175</spage><epage>184</epage><pages>175-184</pages><issn>0962-8924</issn><eissn>1879-3088</eissn><abstract>The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to provide an integrated view of how histone modifications act as ‘countermarks’, ‘landmarks’, and ‘bookmarks’ to displace, recruit, and ‘remember’ the location of regulatory proteins during and shortly after mitosis. These capabilities allow histone marks to help downregulate interphase functions such as transcription during mitosis, to facilitate chromatin events required to accomplish chromosome segregation, and to contribute to the maintenance of epigenetic states through mitosis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23246430</pmid><doi>10.1016/j.tcb.2012.11.005</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0962-8924
ispartof Trends in cell biology, 2013-04, Vol.23 (4), p.175-184
issn 0962-8924
1879-3088
language eng
recordid cdi_proquest_miscellaneous_1367484356
source ScienceDirect Freedom Collection
subjects acetylation
Animals
centromere
Chromatin - metabolism
histone
Histones - metabolism
Humans
methylation
Mitosis
Models, Biological
Pathology
phosphorylation
Protein Processing, Post-Translational
title Histone modifications and mitosis: countermarks, landmarks, and bookmarks
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T04%3A19%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histone%20modifications%20and%20mitosis:%20countermarks,%20landmarks,%20and%20bookmarks&rft.jtitle=Trends%20in%20cell%20biology&rft.au=Wang,%20Fangwei&rft.date=2013-04-01&rft.volume=23&rft.issue=4&rft.spage=175&rft.epage=184&rft.pages=175-184&rft.issn=0962-8924&rft.eissn=1879-3088&rft_id=info:doi/10.1016/j.tcb.2012.11.005&rft_dat=%3Cproquest_cross%3E1367484356%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c437t-fa48f6096b4ed18bac0f548f0cbfd9ae0aa1929d51bff11a81da2ffe9db34ead3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1322732684&rft_id=info:pmid/23246430&rfr_iscdi=true