Vocal cord paralysis during the treatment of mantle cell lymphoma with vincristine

Case description We present a case of a seventy-eight year-old man who developed vocal cord paralysis without any sign of peripheral neuropathy during the treatment of Mantle Cell Lymphoma. He first presented in 2008 with a few bilateral small inguinal lymph nodes. Inguinal lymph node biopsy demonst...

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Bibliographic Details
Published in:International journal of clinical pharmacy 2013-06, Vol.35 (3), p.306-308
Main Authors: Yalin, Serkan Feyyaz, Trabulus, Sinan, Yalin, Ayse Serap, Yalin, Gulsah Yenidunya, Ongoren, Seniz, Altiparmak, Mehmet Riza
Format: Article
Language:English
Subjects:
Aged
Antibodies, Monoclonal, Murine-Derived - adverse effects
Antibodies, Monoclonal, Murine-Derived - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Case Report
Cyclophosphamide - adverse effects
Cyclophosphamide - therapeutic use
Doxorubicin - adverse effects
Doxorubicin - therapeutic use
Drug therapy
Flow Cytometry
Humans
Internal Medicine
Laryngoscopy - methods
Lymphoma
Lymphoma, Mantle-Cell - diagnosis
Lymphoma, Mantle-Cell - drug therapy
Male
Medicine
Medicine & Public Health
Pharmacy
Prednisone - adverse effects
Prednisone - therapeutic use
Speech disorders
Vincristine - administration & dosage
Vincristine - adverse effects
Vincristine - therapeutic use
Vocal Cord Paralysis - chemically induced
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Summary:Case description We present a case of a seventy-eight year-old man who developed vocal cord paralysis without any sign of peripheral neuropathy during the treatment of Mantle Cell Lymphoma. He first presented in 2008 with a few bilateral small inguinal lymph nodes. Inguinal lymph node biopsy demonstrated Mantle Cell Lymphoma. Flow cytometry studies of peripheral blood and bone marrow cells were compatible with Mantle Cell Lymphoma. R-CHOP chemotherapy triweekly (Rituximab; Cyclophosphamide; Adriamycin; Vincristine; and Methylprednisolone) was planned. At the end of the second cycle, the patient complained of hoarseness without any symptoms of dysphagia or odynophagia. Direct flexible laryngoscopy showed bilateral vocal cord paralysis. Vincristine was discontinued and the patient’s voice gradually resolved in about 4 months. Conclusion Vincristine may cause peripheral, autonomic and cranial neuropathies. However cranial nerve involvement is quite uncommon.
ISSN:2210-7703
2210-7711
DOI:10.1007/s11096-013-9751-6