Non-typhoidal Salmonella bacteraemia in elderly patients: an increased risk for endovascular infections, osteomyelitis and mortality

• Published in: Epidemiology and infection 2012-11, Vol.140 (11), p.2037-2044
• Main Authors: CHEN, P. L., LEE, H. C., LEE, N. Y., WU, C. J., LIN, S. H., SHIH, H. I., LEE, C. C., KO, W. C., CHANG, C. M.
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Age groups; Aged; Aged, 80 and over; AIDS; Aneurysm, Infected - diagnosis; Aneurysm, Infected - etiology; Aneurysm, Infected - mortality; Aneurysm, Infected - therapy; Aneurysms; Autoimmune diseases; Bacteremia - complications; Bacteremia - diagnosis; Bacteremia - mortality; Bacteremia - therapy; Bacterial diseases; Bacterial sepsis; Bacteriology; Biological and medical sciences; Cohort Studies; Female; Fundamental and applied biological sciences. Psychology; Human bacterial diseases; Humans; Infections; Infectious diseases; Intestinal infections; Length of Stay - statistics & numerical data; Logistic Models; Lung diseases; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Mortality; Older adults; Osteomyelitis - diagnosis; Osteomyelitis - etiology; Osteomyelitis - mortality; Osteomyelitis - therapy; Respiratory Tract Infections - diagnosis; Respiratory Tract Infections - etiology; Respiratory Tract Infections - mortality; Respiratory Tract Infections - therapy; Retrospective Studies; Risk Factors; Salmonella; Salmonella Infections - complications; Salmonella Infections - diagnosis; Salmonella Infections - mortality; Salmonella Infections - therapy; Taiwan; Treatment Outcome
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268811002901

Non-typhoidal Salmonella (NTS) is a common pathogen causing foodborne infections, bacteraemia, and extra-intestinal focal infections (EFIs) in humans. The study compares the clinical characteristics of elderly patients with NTS bacteraemia with those of young adults. Of 272 adults with NTS bacteraemia identified in this study, 162 (59·6%) were aged ⩾55 years. EFIs were observed in 36% of the 162 patients. The most common EFIs in the elderly patients (⩾55 years) was mycotic aneurysm, followed by pulmonary infections and bone/joint infections. Elderly patients more often had chronic heart, lung, renal and malignant diseases, had more EFIs, and a higher 30-day mortality rate. Independent factors of 30-day mortality in elderly patients were solid-organ tumour [adjusted odds ratio (aOR) 4·4, P=0·003], mycotic aneurysm (aOR 3·7, P=0·023) and shock (aOR 12·1, P