Prevalence of hepatitis B virus infection in The Netherlands in 1996 and 2007

We aimed to assess differences in the prevalence of hepatitis B virus (HBV) infection in The Netherlands between 1996 and 2007, and to identify risk factors for HBV infection in 2007. Representative samples of the Dutch population in 1996 and 2007 were tested for antibodies to hepatitis B core antig...

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Bibliographic Details
Published in:Epidemiology and infection 2012-08, Vol.140 (8), p.1469-1480
Main Authors: HAHNÉ, S. J. M., DE MELKER, H. E., KRETZSCHMAR, M., MOLLEMA, L., VAN DER KLIS, F. R., VAN DER SANDE, M. A. B., BOOT, H. J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age groups
Aged
Antigens
Biological and medical sciences
Child
Child, Preschool
Country of birth
Cross-Sectional Studies
Data Collection
Determinants
Emigration and Immigration
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis antigens
Hepatitis B
Hepatitis B virus
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - prevention & control
Human viral diseases
Humans
Immunization
Infant
Infections
Infectious diseases
Laboratories
Liver cirrhosis
Medical sciences
Microbiology
Middle Aged
Netherlands - epidemiology
P values
Population
Population estimates
Predisposing factors
Prevalence
Prevention
Questionnaires
Serology
Surveys and Questionnaires
Time Factors
Travel
Vaccination
Viral diseases
Viral hepatitis
Young Adult
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Description
Summary:We aimed to assess differences in the prevalence of hepatitis B virus (HBV) infection in The Netherlands between 1996 and 2007, and to identify risk factors for HBV infection in 2007. Representative samples of the Dutch population in 1996 and 2007 were tested for antibodies to hepatitis B core antigen (anti-HBc), hepatitis B surface antigen (HBsAg) and HBV-DNA. In 2007, the weighted anti-HBc prevalence was 3·5% (95% CI 2·2–5·5) and the HBsAg prevalence was 0·2% (95% CI 0·1–0·4). In indigenous Dutch participants, the anti-HBc prevalence was lower in 2007 than in 1996 (P=0·06). First-generation migrants (FGMs) had a 13-fold greater risk of being HBsAg- and/or HBV-DNA-positive than indigenous Dutch participants. In indigenous Dutch participants, risk factors for anti-HBc positivity were older age and having received a blood product before 1990. In FGMs, being of Asian origin was a risk factor. In second-generation migrants, having a foreign-born partner and injecting drug use were risk factors. FGMs are the main target group for secondary HBV prevention in The Netherlands.
ISSN:0950-2688
1469-4409
DOI:10.1017/S095026881100224X