Antioxidant Status and Oxidative Stress in Patients with Chronic ITP

The aim of this study was to establish the antioxidant status and oxidative stress in adult patients with chronic idiopathic thrombocytopenic purpura (ITP). Eighty‐four patients diagnosed with chronic ITP were studied. Fifty‐eight age‐matched healthy subjects were selected as controls. Serum nitroge...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2013-06, Vol.77 (6), p.482-487
Main Authors: Jin, C.‐Q., Dong, H.‐X., Cheng, P.‐P., Zhou, J.‐W., Zheng, B.‐Y., Liu, F.
Format: Article
Language:English
Subjects:
Adult
Antioxidants - analysis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Oxidative Stress - physiology
Purpura, Thrombocytopenic, Idiopathic - blood
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Summary:The aim of this study was to establish the antioxidant status and oxidative stress in adult patients with chronic idiopathic thrombocytopenic purpura (ITP). Eighty‐four patients diagnosed with chronic ITP were studied. Fifty‐eight age‐matched healthy subjects were selected as controls. Serum nitrogen monoxide ( NO), oxidized glutathione (GSSG), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase(SOD), hydrogen peroxide enzyme (CAT), glutathione peroxidase (GSH‐Px), glutathione (GSH) were evaluated by enzyme‐linked immunosorbent assay (ELISA). It was found that serum SOD, CAT, GSH‐Px, GSH, TAS levels were significantly lower in patients with chronic ITP than controls (all P 
ISSN:0300-9475
1365-3083
DOI:10.1111/sji.12048