B-regulatory cells in autoimmunity and immune mediated inflammation

B cells are a source of inhibitory cytokines such as IL-10 and TGF-β. The ability of being B-regulatory cells (B-regs) was shown to be driven by many stimulatory factors such as toll-like receptors, CD40-ligand and others. However, the characterization of B-regs is still underway. B-regs express hig...

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Bibliographic Details
Published in:FEBS letters 2013-06, Vol.587 (13), p.2074-2078
Main Authors: Vadasz, Zahava, Haj, Tharwat, Kessel, Aharon, Toubi, Elias
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - metabolism
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmunity
B-Lymphocytes, Regulatory - immunology
B-Lymphocytes, Regulatory - metabolism
B-regulatory cell
Biomarkers - metabolism
CD4-Positive T-Lymphocytes - immunology
Cytokines - metabolism
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - metabolism
Gene Expression
Humans
Inflammation - immunology
Inflammation - pathology
Regulatory marker
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Summary:B cells are a source of inhibitory cytokines such as IL-10 and TGF-β. The ability of being B-regulatory cells (B-regs) was shown to be driven by many stimulatory factors such as toll-like receptors, CD40-ligand and others. However, the characterization of B-regs is still underway. B-regs express high levels of CD25, CD86, IL-10 and TGF-β. In addition, we propose that semaphorin3A is a regulatory molecule and therefore can serve as one of the additional markers for B-regs. This subset of B cells was able to suppress Th1 proliferation, thus contributing to the maintenance of self-tolerance. Finally, the potentiation of B-reg function should become the aim of many immunomodulatory drugs, contributing to a better control of autoimmune diseases.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2013.05.023