Initial multicentre experience of high-speed myocardial perfusion imaging: comparison between high-speed and conventional single-photon emission computed tomography with angiographic validation

• Published in: European journal of nuclear medicine and molecular imaging 2013-07, Vol.40 (7), p.1084-1094
• Main Authors: Neill, Johanne, Prvulovich, Elizabeth M., Fish, Matthews B., Berman, Daniel S., Slomka, Piotr J., Sharir, Tali, Martin, William H., DiCarli, Marcelo F., Ziffer, Jack A., Bomanji, Jamshed B., Shiti, Dalia, Ben-Haim, Simona
• Format: Article
• Language: English
• Subjects: Angiogenesis; Cardiology; Comparative studies; Coronary Angiography; Coronary Artery Disease - diagnostic imaging; Emissions; Female; Heart; Humans; Imaging; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Myocardial Perfusion Imaging - methods; Nuclear Medicine; Oncology; Original Article; Orthopedics; Radiology; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Tomography; Tomography, Emission-Computed, Single-Photon - methods
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-013-2399-6

Purpose High-speed (HS) single-photon emission computed tomography (SPECT) with a recently developed solid-state camera shows comparable myocardial perfusion abnormalities to those seen in conventional SPECT. We aimed to compare HS and conventional SPECT images from multiple centres with coronary angiographic findings. Methods The study included 50 patients who had sequential conventional SPECT and HS SPECT myocardial perfusion studies and coronary angiography within 3 months. Stress and rest perfusion images were visually analysed and scored semiquantitatively using a 17-segment model by two experienced blinded readers. Global and coronary territorial summed stress scores (SSS) and summed rest scores (SRS) were calculated. Global SSS ≥3 or coronary territorial SSS ≥2 was considered abnormal. In addition the total perfusion deficit (TPD) was automatically derived. TPD >5 % and coronary territorial TPD ≥3 % were defined as abnormal. Coronary angiograms were analysed for site and severity of coronary stenosis; ≥50 % was considered significant. Results Of the 50 patients, 13 (26 %) had no stenosis, 22 (44 %) had single-vessel disease, 6 (12 %) had double-vessel disease and 9 (18 %) had triple-vessel disease. There was a good linear correlation between the visual global SSS and SRS (Spearman’s ρ 0.897 and 0.866, respectively; p