Cardiac cell therapy: boosting mesenchymal stem cells effects

Acute myocardial infarction is a major problem of world public health and available treatments have limited efficacy. Cardiac cell therapy is a new therapeutic strategy focused on regeneration and repair of the injured cardiac muscle. Among different cell types used, mesenchymal stem cells (MSC) hav...

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Bibliographic Details
Published in:Stem cell reviews and reports 2013-06, Vol.9 (3), p.266-280
Main Authors: Samper, E, Diez-Juan, A, Montero, J A, Sepúlveda, P
Format: Article
Language:English
Subjects:
Cell Differentiation
Cell- and Tissue-Based Therapy
Genetic Engineering
Humans
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Myocardial Infarction - therapy
Myocardium - cytology
Myocardium - metabolism
Myocytes, Cardiac - cytology
Myocytes, Cardiac - metabolism
Paracrine Communication
Regeneration
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Summary:Acute myocardial infarction is a major problem of world public health and available treatments have limited efficacy. Cardiac cell therapy is a new therapeutic strategy focused on regeneration and repair of the injured cardiac muscle. Among different cell types used, mesenchymal stem cells (MSC) have been widely tested in preclinical studies and several clinical trials have evaluated their clinical efficacy in myocardial infarction. However, the beneficial effects of MSC in humans are limited due to poor engraftment and survival of these cells, therefore ways to overcome these obstacles should improve efficacy. Different strategies have been used, such as genetically modifying MSC, or preconditioning the cells with factors that potentiate their survival and therapeutic mechanisms. In this review we compile the most relevant approaches used to improve MSC therapeutic capacity and to understand the molecular mechanisms involved in MSC mediated cardiac repair.
ISSN:2629-3269
2629-3277
DOI:10.1007/s12015-012-9353-z