Surgical treatment results of intestinal and diffuse type gastric cancer. Implications for a differentiated therapeutic approach?

Abstract Aim To study the outcome of patients who were surgically treated for primary gastric cancer with specific attention to differences in treatment results for intestinal and diffuse type tumours. Methods All patients who underwent a potentially curative gastric resection between 1995 and 2011...

Full description

Saved in:
Bibliographic Details
Published in:European journal of surgical oncology 2013-07, Vol.39 (7), p.686-693
Main Authors: Stiekema, J, Cats, A, Kuijpers, A, van Coevorden, F, Boot, H, Jansen, E.P.M, Verheij, M, Balague Ponz, O, Hauptmann, M, van Sandick, J.W
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biopsy, Needle
Cohort Studies
Confidence Intervals
Disease-Free Survival
Endoscopy, Digestive System - methods
Female
Gastrectomy - methods
Gastric cancer
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
Intestinal Neoplasms - mortality
Intestinal Neoplasms - pathology
Intestinal Neoplasms - surgery
Laurén classification
Male
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness - pathology
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Netherlands
Outcome
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Surgery
Surgical treatment
Survival Analysis
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Aim To study the outcome of patients who were surgically treated for primary gastric cancer with specific attention to differences in treatment results for intestinal and diffuse type tumours. Methods All patients who underwent a potentially curative gastric resection between 1995 and 2011 in our institute were included. Patient, tumour and treatment characteristics were obtained retrospectively. Binary logistic and Cox regression models were used for multivariate analysis. Results A consecutive series of 132 patients was included. Median follow-up was 53 months. There were no significant differences between patients with intestinal ( N  = 62) versus diffuse type ( N  = 70) gastric cancer with regard to the proportion of patients who underwent (neo)adjuvant treatment. Postoperative mortality was 2%. Pathological T- and N-stage were significantly more advanced for patients with diffuse type tumours. There was a significant difference in the percentage of microscopically irradical resections (2% versus 24%, p  
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2013.02.026