The ectonucleotide pyrophosphatase phosphodiesterase 1 ( ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals

Abstract Background and aims Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 ( ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the ameliorati...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2013-06, Vol.23 (6), p.505-510
Main Authors: Maranghi, M, Prudente, S, D’Erasmo, L, Morini, E, Ciociola, E, Coletta, P, Verrienti, A, Arciello, S, Copetti, M, Pellegrini, F, Santini, S.A, Morano, S, Filetti, S, Trischitta, V
Format: Article
Language:English
Subjects:
Adiposity
Adult
Blood Glucose - analysis
Body Mass Index
Cardiovascular
Cholesterol, HDL - blood
Diabetes Mellitus
Diet
Exercise
Fasting
Female
Gene–treatment interaction
Genotype
glucose
Homeostasis
Humans
Insulin Resistance
Insulin signalling
Life Style
lifestyle
Lifestyle intervention
Male
Middle Aged
Multivariate Analysis
Obesity - blood
Obesity - genetics
Overweight - blood
Overweight - genetics
Overweight-obesity
Phosphoric Diester Hydrolases - genetics
Phosphoric Diester Hydrolases - metabolism
Polymorphism, Genetic
Prevention of type 2 diabetes mellitus
Pyrophosphatases - genetics
Pyrophosphatases - metabolism
triacylglycerols
Triglycerides - blood
Weight Loss
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Summary:Abstract Background and aims Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 ( ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals. Methods and results Two hundred eleven non-diabetic overweight-obese individuals were studied. Body mass index (BMI), fasting glucose, homeostasis model assessment of insulin resistance (HOMA-IR index) and lipid levels were obtained before and after 6-week lifestyle intervention (LI; diet and exercise) and their changes calculated as baseline minus 6-week values. LI decreased BMI, glucose, HOMA-IR and triglyceride levels ( p  
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2011.11.003