Antitumoral effects of vasoactive intestinal peptide in human renal cell carcinoma xenografts in athymic nude mice

Highlights • VIP exerted antitumoral effects in renal cell carcinoma xenografts. • VIP upregulated p53 and decreased nuclear β-catenin translocation. • VIP decreased NFκB, MMP-2, MMP-9, VEGF and CD-34 levels. • VIP led to differentiated tubular organization and less metastatic areas.

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Bibliographic Details
Published in:Cancer letters 2013-08, Vol.336 (1), p.196-203
Main Authors: Vacas, Eva, Arenas, M. Isabel, Muñoz-Moreno, Laura, Bajo, Ana M, Sánchez-Chapado, Manuel, Prieto, Juan C, Carmena, María J
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Angiogenesis
Animals
beta Catenin - metabolism
Carcinoma, Renal Cell - metabolism
ccRCC
Cell adhesion & migration
Cell growth
Cell Line, Tumor
Cell Nucleus - metabolism
Disease
Gene expression
Gene Expression Regulation, Neoplastic
Genotype & phenotype
Hematology, Oncology and Palliative Medicine
Humans
Kidney Neoplasms - metabolism
Male
Medical prognosis
Metastasis
Mice
Mice, Nude
MMP
Neoplasm Metastasis
Neoplasm Transplantation
Neuropeptides
NFκB
Peptides
Proteins
Rodents
Tumors
Vasoactive Intestinal Peptide - pharmacology
VEGF
VIP
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Description
Summary:Highlights • VIP exerted antitumoral effects in renal cell carcinoma xenografts. • VIP upregulated p53 and decreased nuclear β-catenin translocation. • VIP decreased NFκB, MMP-2, MMP-9, VEGF and CD-34 levels. • VIP led to differentiated tubular organization and less metastatic areas.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.04.033