Safety and Efficacy of Ultra-high-dose, Short-term Thrombolysis with rt-PA for Acute Lower Limb Ischemia

Objectives The evaluation of success and complication rates of ultra high-dose recombinant tissue plasminogen activator (rt-PA) administered over a short time frame in the treatment of acute lower limb ischemia. Methods This was a prospective single-center study. The outcome of treatment in 97 patie...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2013-07, Vol.46 (1), p.118-123
Main Authors: Falkowski, A, Poncyljusz, W, Samad, R.A, Mokrzyński, S
Format: Article
Language:English
Subjects:
Acute Disease
Acute limb ischemia
Adult
Aged
Aged, 80 and over
Catheter-directed thrombolysis
Female
Fibrinolytic Agents - adverse effects
Humans
Ischemia - drug therapy
Leg - blood supply
Male
Middle Aged
Prospective Studies
Recombinant Proteins - administration & dosage
Recombinant Proteins - adverse effects
Recombinant tissue-type plasminogen activator
Surgery
Thrombolytic Therapy - methods
Time Factors
Tissue Plasminogen Activator - administration & dosage
Tissue Plasminogen Activator - adverse effects
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Summary:Objectives The evaluation of success and complication rates of ultra high-dose recombinant tissue plasminogen activator (rt-PA) administered over a short time frame in the treatment of acute lower limb ischemia. Methods This was a prospective single-center study. The outcome of treatment in 97 patients with acute limb ischemia (
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2013.04.016