Clinical study of hemodynamic changes comparing 4% articaine hydrochloride with 1:100,000 and 1:200,000 epinephrine

Objective To evaluate hemodynamic changes with the use of 4% articaine and 2 different concentrations of epinephrine (1:100,000 and 1:200,000) in the surgical removal of symmetrically positioned lower third molars. Study Design A prospective, randomized, double-blind clinical trial was carried out i...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2013-07, Vol.116 (1), p.e14-e22
Main Authors: de Morais, Hécio Henrique Araújo, DDS, Msc, Holanda Vasconcellos, Ricardo José, DDS, MSc, PhD, de Santana Santos, Thiago, DDS, MSc, Rocha, Nelson Studart, DDS, MSc, da Costa Araújo, Fábio Andrey, DDS, de Carvalho, Ricardo Wathson Feitosa, DDS
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia, Dental - methods
Anesthetics, Local - pharmacology
Blood Pressure
Carticaine - pharmacology
Dentistry
Double-Blind Method
Epinephrine - pharmacology
Female
Heart Rate
Hemodynamics - drug effects
Humans
Male
Molar, Third - surgery
Oxygen - blood
Prospective Studies
Surgery
Tooth Extraction
Vasoconstrictor Agents - pharmacology
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Summary:Objective To evaluate hemodynamic changes with the use of 4% articaine and 2 different concentrations of epinephrine (1:100,000 and 1:200,000) in the surgical removal of symmetrically positioned lower third molars. Study Design A prospective, randomized, double-blind clinical trial was carried out involving 42 patients each undergoing 2 surgeries on separate occasions under local anesthesia with 4% articaine and either epinephrine 1:100,000 or 1:200,000. The following parameters were assessed at 4 different moments: systolic, diastolic, and mean blood pressure; heart rate; oxygen saturation; rate pressure product (RPP); and pressure rate quotient (PRQ). Results The concentration of epinephrine did not affect diastolic blood pressure or oxygen saturation during the surgeries. Significant differences between were detected for heart rate, RPP, and PRQ ( P < .05). Conclusions The epinephrine concentration (1:100,000 or 1:200,000) in a 4% articaine solution influences hemodynamic parameters without perceptible clinical changes in healthy patients undergoing lower third molar removal.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2011.10.043