Two-pass dual-energy CT imaging for simultaneous detection, characterization, and volume measurement of urinary stones with excretory-phase CT urography alone: a phantom study

Purpose To evaluate if two-pass dual-energy CT imaging—i.e., simultaneous three-material and two-material decomposition analysis—can depict and characterize urinary stones in various concentrations of iodine solution in vitro. Materials and methods Twelve urinary stones were scanned with a dual-sour...

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Bibliographic Details
Published in:Japanese journal of radiology 2013-06, Vol.31 (6), p.393-400
Main Authors: Takahashi, Satoru, Itoh, Toshihide, Niikawa, Hidekazu, Shikata, Atsushi, Murakami, Emi, Tsunoda, Hiroshi, Yoshioka, Toshiaki, Tsujihata, Masao, Yamamoto, Hiroshi
Format: Article
Language:English
Subjects:
Contrast Media
Humans
Imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Original Article
Phantoms, Imaging
Predictive Value of Tests
Radiology
Radiotherapy
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
Urinary Calculi - diagnostic imaging
Urography
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Summary:Purpose To evaluate if two-pass dual-energy CT imaging—i.e., simultaneous three-material and two-material decomposition analysis—can depict and characterize urinary stones in various concentrations of iodine solution in vitro. Materials and methods Twelve urinary stones were scanned with a dual-source CT scanner. First, each stone (in a saline-filled tube) underwent single- and dual-energy mode CT scans in order to measure the volume of the stone. Each stone was then placed in various concentrations of contrast medium and scanned in dual-energy mode to calculate its volume via three-material decomposition analysis. Two-pass dual-energy CT imaging analysis software for the Matlab environment, which was developed specifically to process simultaneous three-material and two-material decomposition, was applied to characterize and calculate the volume of each stone. Results Although the virtual non-contrast images from three-material decomposition analysis clearly visualized all of the stones in contrast medium with up to 80 mgI/mL, the volumes of the uric acid stones were overestimated. Two-pass dual-energy CT imaging was able to depict and characterize non-uric-acid stones in diluted contrast medium with up to 80 mgI/mL, whereas uric acid stones were correctly evaluated in diluted contrast medium with 40 mgI/mL or less. Conclusions Two-pass dual-energy CT imaging is able to depict and characterize urinary stones in contrast medium.
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-013-0209-5