Molecular epidemiology of Escherichia coli O25b-ST131 isolates causing community-acquired UTIs in Mexico

Abstract Escherichia coli is a common uropathogen causing community-acquired urinary tract infections (UTIs). Out of 4735 E. coli community-acquired UTIs, 10.2% were extended spectrum β-lactamases (ESBL)-producing. The identified ESBL types were CTX-M-15 (96.4%), SHV-2a (3%), and TLA-1 (1%). Of the...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2013-07, Vol.76 (3), p.396-398
Main Authors: Reyna-Flores, Fernando, Barrios, Humberto, Garza-Ramos, Ulises, Sánchez-Pérez, Alejandro, Rojas-Moreno, Teresa, Uribe-Salas, Felipe J, Fagundo-Sierra, Reynero, Silva-Sanchez, Jesus
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology
beta-Lactam Resistance - genetics
beta-Lactamases - genetics
Child
Child, Preschool
Community isolates
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
CTX-M-15
E. coli
Escherichia coli - enzymology
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Female
Humans
Infectious Disease
Internal Medicine
Male
Mexico - epidemiology
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Molecular Typing
O25b-ST131
Plasmids - genetics
PMQR genes
Quinolones - pharmacology
Urinary Tract Infections - epidemiology
Urinary Tract Infections - microbiology
UTIs
Young Adult
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Summary:Abstract Escherichia coli is a common uropathogen causing community-acquired urinary tract infections (UTIs). Out of 4735 E. coli community-acquired UTIs, 10.2% were extended spectrum β-lactamases (ESBL)-producing. The identified ESBL types were CTX-M-15 (96.4%), SHV-2a (3%), and TLA-1 (1%). Of the isolates, 94.6% tested positive for plasmid-mediated quinolone resistance (PMQR) genes ( aac(6′)-lb-cr [92.1%] and qepA1 [7%] and for qnr -determinants [3.5%]). E. coli O25b-ST131 was identified in 25% of the isolates that harbor a non-conjugative 160-kb plasmid (IncFIA) containing the CTX-M-15, and all of these isolates were found to contain PMQR genes. This work can be useful in modeling the potential impact that may have on community-acquired UTIs in Mexico.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2013.03.026