Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population

• Published in: Journal of international medical research 2013-04, Vol.41 (2), p.340-346
• Main Authors: Chen, Qian, Huang, Chang-Quan, Hu, Xiu-Ying, Li, Song-Bing, Zhang, Xue-Mei
• Format: Article
• Language: English
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer Disease - genetics; Apolipoprotein E4 - genetics; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Case-Control Studies; China; CLOCK Proteins - genetics; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Demography; Female; Gene Frequency - genetics; General pharmacology; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Medical sciences; Neurology; Organic mental disorders. Neuropsychology; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymorphism, Single Nucleotide - genetics; Protein Isoforms - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060513476430

Objective To examine the association between the circadian locomotor output cycles kaput (CLOCK) gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease in Chinese people. Methods This case–control study determined apolipoprotein E (APOE) and CLOCK rs1554483 G/C genotypes using polymerase chain reaction restriction fragment length polymorphism. Results Unrelated patients with Alzheimer's disease (n = 130) and healthy controls (n = 188) were analysed for an association between the CLOCK gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease. In the whole sample and in APOE ɛ4 isoform noncarriers, the prevalence of CLOCK gene rs1554483 G allele carriers was significantly higher in patients with Alzheimer's disease than in controls. Among APOE ɛ4 carriers, the prevalence of CLOCK rs1554483 G allele carriers was not significantly different between patients with Alzheimer's disease and controls. Conclusion Among APOE ɛ4 noncarriers, but not APOE ɛ4 carriers, the CLOCK rs1554483 G allele was associated with increased susceptibility to Alzheimer's disease.