Relationship between arterial stiffness and variability in systolic blood pressure during a single clinic visit in patients with hypertension

Objective To examine factors affecting systolic blood pressure (SBP) variability during a single clinic visit, in treated hypertensive patients. Methods Hypertensive patients were recruited to this observational study. Blood pressure was measured using an automated blood pressure monitor when each p...

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Bibliographic Details
Published in:Journal of international medical research 2013-04, Vol.41 (2), p.325-333
Main Authors: Masugata, Hisashi, Senda, Shoichi, Inukai, Michio, Himoto, Takashi, Hosomi, Naohisa, Imachi, Hitomi, Murao, Koji, Okada, Hiroki, Goda, Fuminori
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Ambulatory Care
Ankle - blood supply
Ankle - physiopathology
Arterial hypertension. Arterial hypotension
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Cardiology. Vascular system
Demography
Female
General pharmacology
Humans
Hypertension - physiopathology
Linear Models
Male
Medical sciences
Middle Aged
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Systole - physiology
Vascular Stiffness - physiology
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Summary:Objective To examine factors affecting systolic blood pressure (SBP) variability during a single clinic visit, in treated hypertensive patients. Methods Hypertensive patients were recruited to this observational study. Blood pressure was measured using an automated blood pressure monitor when each patient arrived at the outpatient clinic and again when they saw the physician. Mean SBP and SBP variability during a single clinic visit were calculated. The cardio–ankle vascular index (CAVI), as a marker of arterial stiffness, was also measured. Results A total of 57 treated hypertensive patients (mean age 71 years) were included in the study. The mean SBP was positively correlated with age (r = 0.457), while SBP variability was positively correlated with age (r = 0.383), CAVI (r = 0.330), and glycosylated haemoglobin (r = 0.345) and triglyceride levels (r = 0.299). Conclusion Variability in SBP during a single clinic visit showed better correlations with arterial stiffness and risk factors for atherosclerosis than did mean SBP. Large SBP variability during a single clinic visit may reflect progression of atherosclerosis, in treated hypertensive patients.
ISSN:0300-0605
1473-2300
DOI:10.1177/0300060513476590