Prognostic factors for supraglottic laryngeal carcinoma: Importance of the unfit patient

Background The purpose of this study was to define prognostic factors for supraglottic laryngeal cancer that may influence management. Methods This ethics‐approved study captured information on patients who presented with supraglottic laryngeal cancer between 1967 and 2008. Endpoints were local/ulti...

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Bibliographic Details
Published in:Head & neck 2013-07, Vol.35 (7), p.949-958
Main Authors: Smee, Robert I., De-loyde, Katie J., Broadley, Kathryn, Williams, Janet R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
cancer-specific survival
Carcinoma in Situ - diagnosis
Carcinoma in Situ - mortality
Carcinoma in Situ - therapy
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - therapy
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Laryngeal Neoplasms - diagnosis
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - therapy
local control
Male
Middle Aged
Prognosis
radiotherapy
Regression Analysis
Retrospective Studies
supraglottic laryngeal cancer
Survival Rate
Treatment Outcome
ultimate local control
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Summary:Background The purpose of this study was to define prognostic factors for supraglottic laryngeal cancer that may influence management. Methods This ethics‐approved study captured information on patients who presented with supraglottic laryngeal cancer between 1967 and 2008. Endpoints were local/ultimate failure and cancer‐specific survival (CSS). Analysis was performed using chi‐square, Fisher exact test, and logistic regression. Kaplan–Meier and Cox regression analysis were used to describe time‐to‐event data. Results Three hundred sixty‐nine patients were analyzed. Two hundred seventeen patients received radiotherapy, 30 were treated with surgery, and 122 were treated with radiotherapy and surgery. The 5‐year ultimate local control and CSS rates were 79.5% and 62.8%. Treatment type was a univariate predictor for outcome; however, it was not an independent predictor for ultimate local control or CSS. Conclusions This study highlights the fact that by documenting information it is possible to define prognostic factors. It also shows the importance of adjusting for clinical predictors such as patients being unfit for surgery. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.23061